HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

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dc.contributor.author Patel, Manthan
dc.contributor.author Patel, Divyesh
dc.contributor.author Datta, Subhamoy
dc.contributor.author Singh, Umashankar
dc.date.accessioned 2020-03-07T14:28:11Z
dc.date.available 2020-03-07T14:28:11Z
dc.date.issued 2020-01
dc.identifier.citation Patel, Manthan; Patel, Divyesh; Datta, Subhamoy and Singh, Umashankar, "HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1", bioRxiv, Cold Spring Harbor Laboratory, DOI: 10.1101/2020.01.08.898494, Jan. 2020. en_US
dc.identifier.uri DOI: 10.1101/2020.01.08.898494
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/5184
dc.description.abstract The antineoplastic agent Givinostat inhibits histone deacetylases. We present here our finding that the DNA-binding of human CGGBP1 is also inhibited by Givinostat. CGGBP1, a DNA-binding protein, is required for cancer cell proliferation. In our quest to exploit the potential anti-proliferative effects of CGGBP1 inhibition, we have developed a simple screening assay to identify chemical inhibitors of DNA-protein interactions. We have applied this screen for human CGGBP1 on a library of 1685 compounds and found that Givinostat is a direct inhibitor of CGGBP1-DNA interaction. The mechanism of action of Givinostat should thus extend beyond HDACs to include the inhibition of the myriad functions of CGGBP1 that depend on its binding to the DNA.
dc.description.statementofresponsibility by Manthan Patel, Divyesh Patel, Subhamoy Datta and Umashankar Singh
dc.language.iso en_US en_US
dc.publisher Cold Spring Harbor Laboratory en_US
dc.title HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1 en_US
dc.type Pre-Print en_US
dc.relation.journal bioRxiv

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