Enhancing aqueous solubility and antibacterial activity of curcumin by complexing with cell-penetrating octaarginine

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dc.contributor.author Ratrey, Poonam
dc.contributor.author Dalvi, Sameer V.
dc.contributor.author Mishra, Abhijit
dc.date.accessioned 2020-08-07T14:26:30Z
dc.date.available 2020-08-07T14:26:30Z
dc.date.issued 2020-07
dc.identifier.citation Ratrey, Poonam; Dalvi, Sameer V. and Mishra, Abhijit, “Enhancing aqueous solubility and antibacterial activity of curcumin by complexing with cell-penetrating octaarginine”, ACS Omega, DOI: 10.1021/acsomega.0c02321, vol. 5, no. 30, pp. 19004-19013, Jul. 2020. en_US
dc.identifier.issn 2470-1343
dc.identifier.uri https://doi.org/10.1021/acsomega.0c02321
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/5607
dc.description.abstract Bacterial resistance to antimicrobial drugs is one of the biggest threats to human health and novel drugs, and strategies are needed to obviate this resistance crisis. An innovative strategy for designing novel antimicrobial drugs is based on the hybridization of an antimicrobial agent with a second functional entity. Here, we use a cell-penetrating peptide�octaarginine (R8) as the second functional entity and develop a complex or hybrid of R8 and curcumin that possibly targets the bacterial cell membrane. Minimum inhibitory concentration assays show that the antibacterial activity of the complex is enhanced in a synergistic manner and rapid killing kinetics are obtained, emphasizing a bactericidal mode of action. In addition, electron microscopy images reveal bacterial membrane disruption by the complex. The R8�curcumin complex also displays activity against HeLa cells.
dc.description.statementofresponsibility by Poonam Ratrey, Sameer V. Dalvi and Abhijit Mishra
dc.language.iso en_US en_US
dc.publisher American Chemical Society en_US
dc.title Enhancing aqueous solubility and antibacterial activity of curcumin by complexing with cell-penetrating octaarginine en_US
dc.type Article en_US
dc.relation.journal ACS Omega


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