New curcumin-trimesic acid cocrystal and anti-invasion activity of curcumin multicomponent solids against 3D tumor models

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dc.contributor.author Sathisaran, Indumathi
dc.contributor.author Bhatia, Dhiraj
dc.contributor.author Dalvi, Sameer V.
dc.date.accessioned 2020-08-07T14:26:30Z
dc.date.available 2020-08-07T14:26:30Z
dc.date.issued 2020-09
dc.identifier.citation Sathisaran, Indumathi; Bhatia, Dhiraj and Dalvi, Sameer V., "New curcumin-trimesic acid cocrystal and anti-invasion activity of curcumin multicomponent solids against 3D tumor models", International Journal of Pharmaceutics, DOI: 10.1016/j.ijpharm.2020.119667, vol. 587, Sep. 2020. en_US
dc.identifier.issn 0378-5173
dc.identifier.uri http://dx.doi.org/10.1016/j.ijpharm.2020.119667
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/5610
dc.description.abstract Curcumin (CUR) is a Biopharmaceutics Classification System (BCS) class IV drug with poor aqueous solubility and low permeability. The dissolution of CUR can be enhanced through the cocrystallization approach. In this work, we report a new cocrystal phase of CUR with trimesic acid (TMA) with the enhanced dissolution of CUR. Cytotoxicity and cell invasion assays were conducted on (2D) monolayers and three-dimensional (3D) tumor models of triple-negative breast cancer (TNBC) cells, MDA-MB-231 using the new CUR-TMA cocrystal phase along with different CUR solid forms prepared in our previous works. The cytotoxicity and internalization assays conducted on 2D monolayers indicated that all CUR multicomponent solid forms except Curcumin-Folic Acid Dihydrate (CUR-FAD) (1:1) coamorphous solid exhibited enhanced bioavailability than unprocessed CUR. Cell invasion assay conducted on 3D tumor spheroid models showed that Curcumin-Hydroxyquinol (CUR-HXQ) cocrystal completely inhibited cell invasion whereas CUR-FAD (1:1) coamorphous solid induced enhanced invasion of cells from spheroid models.
dc.description.statementofresponsibility by Indumathi Sathisaran, Dhiraj Devidas Bhatia and Sameer Vishvanath Dalvi
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Curcumin en_US
dc.subject Trimesic acid en_US
dc.subject Cocrystal en_US
dc.subject Coamorphous solid en_US
dc.subject Cell invasion en_US
dc.subject 2D monolayer en_US
dc.subject 3D tumor model en_US
dc.title New curcumin-trimesic acid cocrystal and anti-invasion activity of curcumin multicomponent solids against 3D tumor models en_US
dc.type Article en_US
dc.relation.journal International Journal of Pharmaceutic


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