Biomedical application, drug delivery and metabolic pathway of antiviral nanotherapeutics for combating viral pandemic: a review

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dc.contributor.author Mukherjee, Santanu
dc.contributor.author Mazumder, Payal
dc.contributor.author Joshi, Madhvi
dc.contributor.author Joshi, Chaitanya
dc.contributor.author Dalvi, Sameer V.
dc.contributor.author Kumar, Manish
dc.date.accessioned 2020-09-16T07:43:48Z
dc.date.available 2020-09-16T07:43:48Z
dc.date.issued 2020-12
dc.identifier.citation Mukherjee, Santanu; Mazumder, Payal; Joshi, Madhvi; Joshi, Chaitanya; Dalvi, Sameer V. and Kumar, Manish, "Biomedical application, drug delivery and metabolic pathway of antiviral nanotherapeutics for combating viral pandemic: a review", Environmental Research, DOI: 10.1016/j.envres.2020.110119, vol. 191, Dec. 2020. en_US
dc.identifier.issn 0013-9351
dc.identifier.uri 10.1016/j.envres.2020.110119
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/5699
dc.description.abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a neoteric virus belonging to the beta coronavirus class has created a global health concern, responsible for an outbreak of severe acute respiratory illness, the COVID-19 pandemic. Infected hosts exhibit diverse clinical features, ranging from asymptomatic to severe symptoms in their genital organs, respiratory, digestive, and circulatory systems. Considering the high transmissibility (R0: ?6.0) compared to Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV, the quest for the clinical development of suitable antiviral nanotherapeutics (NTPs) is incessant. We are presenting a systematic review of the literature published between 2003 and 2020 to validate the hypothesis that the pharmacokinetics, collateral acute/chronic side effects of nano drugs and spike proteins arrangement of coronaviruses can revolutionize the therapeutic approach to cure COVID-19. Our aim is also to critically assess the slow release kinetics and specific target site chemical synthesis influenced competence of NTPs and nanotoxicity based antiviral actions, which are commonly exploited in the synthesis of modulated nanomedicines. The pathogenesis of novel virulent pathogens at the cellular and molecular levels are also considered, which is of utmost importance to characterize the emerging nano-drug agents as diagnostics or therapeutics or viral entry inhibitors. Such types of approaches trigger the scientists and policymakers in the development of a conceptual framework of nano-biotechnology by linking nanoscience and virology to present a smart molecular diagnosis/treatment for pandemic viral infections.
dc.description.statementofresponsibility by Santanu Mukherjee, Payal Mazumder, Madhvi Joshi, Chaitanya Joshi, Sameer V. Dalvi and Manish Kumar
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject SARS-CoV-2 en_US
dc.subject COVID-19 en_US
dc.subject Nanotherapeutics en_US
dc.subject Viral infection en_US
dc.subject Nanomedicine en_US
dc.subject Immunity en_US
dc.title Biomedical application, drug delivery and metabolic pathway of antiviral nanotherapeutics for combating viral pandemic: a review en_US
dc.type Article en_US
dc.relation.journal Environmental Research


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