Programmable DNA nanodevices for applications in neuroscience

Show simple item record Hivare, Pravin|Panda, Chinmaya Gupta, Sharad Bhatia, Dhiraj
dc.coverage.spatial United States of America 2021-01-21T12:13:30Z 2021-01-21T12:13:30Z 2021-02
dc.identifier.citation Hivare, Pravin; Panda, Chinmaya; Gupta, Sharad and Bhatia, Dhiraj, “Programmable DNA nanodevices for applications in neuroscience”, ACS Chemical Neuroscience, DOI: 10.1021/acschemneuro.0c00723, vol. 12, no. 3, pp. 363-377, Feb. 2021. en_US
dc.identifier.issn 1948-7193
dc.description.abstract The broad area of neuroscience has witnessed an increasing exploitation of a variety of synthetic biomaterials with controlled nanosized features. Different bionanomaterials offer very peculiar physicochemical and biochemcial properties contributing to the development of novel imaging devices toward imaging the brain, or as smartly functionalized scaffolds, or diverse tools contributing toward a better understanding of nervous tissue and its functions. DNA nanotechnology-based devices and scaffolds have emerged as ideal materials for cellular and tissue engineering due to their very biocompatible properties, robust adaptation with diverse biological systems, and biosafety in terms of reduced immune response triggering. Here we present technologies with respect to DNA nanodevices that are designed to better interact with nervous systems like neural cells, advanced molecular imaging technologies for imaging brain, biomaterials in neural regeneration, neuroprotection, and targeted delivery of drugs and small molecules across the blood-brain barrier. Along with comments regarding the progress of DNA nanotechnology in neuroscience, we also present a perspective on challenges and opportunities for applying DNA nanotechnology in applications pertaining to neurosciences.
dc.description.statementofresponsibility by Pravin Hivare, Chinmaya Panda, Sharad Gupta and Dhiraj Bhatia
dc.language.iso en_US en_US
dc.publisher American Chemical Society en_US
dc.subject Neuroscience en_US
dc.subject Nanotechnology en_US
dc.subject DNA nanotechnology en_US
dc.subject Protein misfolding en_US
dc.subject Blood-brain barrier en_US
dc.title Programmable DNA nanodevices for applications in neuroscience en_US
dc.type Article en_US
dc.relation.journal ACS Chemical Neuroscience

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