Coalescence of co-infection and antimicrobial resistance with SARS-CoV-2 infection: the blues of post-COVID-19 world

Show simple item record Mazumder, Payal Kalamdhad, Ajay Chaminda, G. G. Tushara Kumar, Manish
dc.coverage.spatial United States of America 2021-03-06T15:08:14Z 2021-03-06T15:08:14Z 2021-02
dc.identifier.citation Mazumder, Payal; Kalamdhad, Ajay; Chaminda, G. G. Tushara and Kumar, Manish, "Coalescence of co-infection and antimicrobial resistance with SARS-CoV-2 infection: the blues of post-COVID-19 world", Case Studies in Chemical and Environmental Engineering, DOI: 10.1016/j.cscee.2021.100093, Feb. 2021. en_US
dc.identifier.issn 2666-0164
dc.description.abstract In viral respiratory infections, bacterial co-pathogens are widely known to co-infect, and they significantly increase the morbidity and mortality rate. During the influenza season, the advent of 2019-nCoV (novel coronavirus) has led to the widespread use of oral and intravenous antibiotics and inhibitors of neuraminidase enzyme. Owing to causes such as extended intubation, the ubiquitous use of intrusive catheters, and compromised host immunity, coronavirus disease (COVID-19) patients are at heightened risk of secondary bacterial and fungal infections, leading to the difficulty in their treatment. Apart from the pandemic, the primary risk is a likely surge in multidrug resistance. In this work, we evaluated the coalescence of present co-infection alongside the COVID-19 and post-pandemic antimicrobial resistance due to high ongoing drug use for the treatment of COVID-19. We found that while there is currently limited evidence of bacterial infections in COVID-19, available proof supports the restricted use of antibiotics from an antibiotic stewardship viewpoint, primarily upon entry. Paramount attempts should be made to collect sputum and blood culture samples as well as pneumococcal urinary antigen monitoring in order to endorse stringent antibiotic usage. For antimicrobial stewardship, inflammatory markers like procalcitonin have been added, but such biomarkers are typically upraised in COVID-19. Antimicrobials cannot be completely removed in wastewater treatment plants (WWTPs) and once they enter the water environment, possesses a great risk of inducing resistance to drugs in microbes. Hence, their prescription and administrations should be regulated and alternate solutions such as vaccines, preventive measures and personal hygiene should be given top priority. It is imperative to establish an antimicrobial strategy discrete to COVID-19, as this pandemic has caused an outbreak of numerous other associated diseases and has the potential to drive microbial resistance. Coordinated plans are essential for this at the citizen, health-care and policy levels.
dc.description.statementofresponsibility by Payal Mazumder, Ajay Kalamdhad, G. G. Tushara Chaminda and Manish Kumar
dc.language.iso en-Us en_US
dc.publisher Elsevier en_US
dc.subject SARS-CoV-2 en_US
dc.subject COVID-19 en_US
dc.subject Antimicrobial resistance en_US
dc.subject Antibiotics en_US
dc.subject Co-infection en_US
dc.title Coalescence of co-infection and antimicrobial resistance with SARS-CoV-2 infection: the blues of post-COVID-19 world en_US
dc.type Article en_US
dc.relation.journal Case Studies in Chemical and Environmental Engineering

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