Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants

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dc.contributor.author Keshri, Priyanka Kumari
dc.contributor.author Rai, Nilesh
dc.contributor.author Verma, Ashish
dc.contributor.author Kamble, Swapnil C.
dc.contributor.author Barik, Suvakanta
dc.contributor.author Mishra, Pradeep
dc.contributor.author Singh, Santosh Kumar
dc.contributor.author Salvi, Prafull
dc.contributor.author Gautam, Vibhav
dc.coverage.spatial United Kingdom
dc.date.accessioned 2021-05-20T05:13:46Z
dc.date.available 2021-05-20T05:13:46Z
dc.date.issued 2021-05
dc.identifier.citation Keshri, Priyanka Kumari; Rai, Nilesh; Verma, Ashish; Kamble, Swapnil C.; Barik, Suvakanta; Mishra, Pradeep; Singh, Santosh Kumar; Salvi, Prafull and Gautam, Vibhav, "Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants", Mycological Progress, DOI: 10.1007/s11557-021-01695-8, vol. 20, no. 5, pp. 577-594, May 2021. en_US
dc.identifier.issn 1617-416X
dc.identifier.issn 1861-8952
dc.identifier.uri http://dx.doi.org/10.1007/s11557-021-01695-8
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/6511
dc.description.abstract Endophytes are endosymbiotic fungi or bacteria that invade and colonize the plant tissue without harming their respective host. Since fungal endophytes live inside the host tissues, their effective isolation and identification is an important step. Endophytic fungi produce bioactive metabolites with unique chemical structures, which may help in improving the physiological condition of both the plants and endophytes. Endophytic fungi are a potent source of all major classes of secondary metabolites including terpenoids, non-ribosomal peptides, polyketides, and alkaloids. With the increase in the number of diseases and human health problems, an intensive search for new sources and effective metabolites is now in progress. The bioactive metabolites produced by the fungal endophytes are competent and effective against various diseases such as cancer, diabetes, infectious diseases, immunological disorders, and cardiovascular diseases. The present review summarizes the efficient approaches used for the screening of fungal endophytes, extraction, and purification of bioactive metabolites along with OMICS based study of endophytes. Along with this, the pharmaceutical importance of novel bioactive metabolites and their efficient production from fungal endophytes using various approaches like genetic engineering, use of elicitors, and precursor feeding are also discussed.
dc.description.statementofresponsibility by Priyanka Kumari Keshri, Nilesh Rai, Ashish Verma, Swapnil C. Kamble, Suvakanta Barik, Pradeep Mishra, Santosh Kumar Singh, Prafull Salvi and Vibhav Gautam
dc.format.extent vol. 20, no. 5, pp. 577-594
dc.language.iso en_US en_US
dc.publisher Springer en_US
dc.subject Fungal endophyte en_US
dc.subject Genomics en_US
dc.subject Secondary metabolite en_US
dc.subject Transcriptomics en_US
dc.title Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants en_US
dc.type Article en_US
dc.relation.journal Mycological Progress


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