Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood-brain barrier model

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dc.contributor.author Guo, Zhiling
dc.contributor.author Zhang, Peng
dc.contributor.author Chakraborty, Swaroop
dc.contributor.author Chetwynd, Andrew J.
dc.contributor.author Abdolahpur Monikh, Fazel
dc.contributor.author Stark, Christopher
dc.contributor.author Ali-Boucetta, Hanene
dc.contributor.author Wilson, Sandra
dc.contributor.author Lynch, Iseult
dc.contributor.author Valsami-Jones, Eugenia
dc.coverage.spatial United States of America
dc.date.accessioned 2012-09-26T07:22:31Z
dc.date.available 2012-09-26T07:22:31Z
dc.date.issued 2021-07
dc.identifier.citation Guo, Zhiling; Zhang, Peng; Chakraborty, Swaroop; Chetwynd, Andrew J.; Abdolahpur Monikh, Fazel; Stark, Christopher; Ali-Boucetta, Hanene; Wilson, Sandra; Lynch, Iseult and Valsami-Jones, Eugenia, “Biotransformation modulates the penetration of metallic nanomaterials across an artificial bloodbrain barrier model”, Proceedings of the National Academy of Sciences (PNAS), DOI: 10.1073/pnas.2105245118, vol. 118, no. 28, Jul. 2021. en_US
dc.identifier.issn 0027-8424
dc.identifier.issn 1091-6490
dc.identifier.uri https://doi.org/10.1073/pnas.2105245118
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/6643
dc.description.abstract Understanding the potential of nanomaterials (NMs) to cross the blood–brain barrier (BBB), as a function of their physicochemical properties and subsequent behavior, fate, and adverse effect beyond that point, is vital for evaluating the neurological effects arising from their unintentional entry into the brain, which is yet to be fully explored. This is not only due to the complex nature of the brain but also the existing analytical limitations for characterization and quantification of NMs in the complex brain environment. By using a fit-for-purpose analytical workflow and an in vitro BBB model, we show that the physiochemical properties of metallic NMs influence their biotransformation in biological matrices, which in turn modulates the transport form, efficiency, amounts, and pathways of NMs through the BBB and, consequently, their neurotoxicity. The data presented here will support in silico modeling and prediction of the neurotoxicity of NMs and facilitate the tailored design of safe NMs.
dc.description.statementofresponsibility by Zhiling Guo, Peng Zhang, Swaroop Chakraborty, Andrew J. Chetwynd, Fazel Abdolahpur Monikh, Christopher Stark, Hanene Ali-Boucetta, Sandra Wilson, Iseult Lynch and Eugenia Valsami-Jones
dc.format.extent vol. 118, no. 28
dc.language.iso en_US en_US
dc.publisher National Academy of Sciences en_US
dc.subject Nanomaterials en_US
dc.subject Blood-brain barrier en_US
dc.subject Neurotoxicity en_US
dc.subject Single-particle ICP-MS en_US
dc.subject Synchrotron en_US
dc.title Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood-brain barrier model en_US
dc.type Article en_US
dc.relation.journal Proceedings of the National Academy of Sciences (PNAS)


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