Small molecule-mediated induction of endoplasmic reticulum stress in cancer cells

Show simple item record Pandey, Shalini Sharma, Virender Kumar Lahiri, Mayurika Basu, Sudipta
dc.coverage.spatial United Kingdom 2012-09-26T07:22:31Z 2012-09-26T07:22:31Z 2021-07
dc.identifier.citation Pandey, Shalini; Sharma, Virender Kumar; Lahiri, Mayurika and Basu, Sudipta, “Small molecule-mediated induction of endoplasmic reticulum stress in cancer cells”, RSC Medicinal Chemistry, DOI: 10.1039/D1MD00095K, vol. 12, no. 9, pp. 1604-1611, Jul. 2021. en_US
dc.identifier.issn 2632-8682
dc.description.abstract Endoplasmic reticulum (ER) is one of the crucial sub-cellular organelles controlling myriads of functions including protein biosynthesis, folding, misfolding and unfolding. As a result, dysregulation of these pathways in ER is implicated in cancer development and progression. Subsequently, targeting ER in cancer emerged as interesting unorthodox strategy in next-generation anticancer therapy. However, development of small molecules to selectively target ER for cancer therapy remained elusive and unexplored. To address this, herein, we have developed a novel small molecule library of sulfonylhydrazide-hydrazone through a short and concise chemical synthetic strategy. We identified a fluorescent small molecule that localized into the endoplasmic reticulum (ER) of HeLa cells, induced ER stress followed by triggering autophagy which was subsequently inhibited by chloroquine (autophagy inhibitor) to initiate apoptosis. This small molecule showed remarkable cancer cell killing efficacy in different cancer cells as mono and combination therapy with chloroquine, thus opening a new direction to illuminate ER-biology towards the development of novel anticancer therapeutics.
dc.description.statementofresponsibility by Shalini Pandey, Virender Kumar Sharma, Mayurika Lahiri and Sudipta Basu
dc.format.extent vol. 12, no. 9, pp. 1604-1611
dc.language.iso en_US en_US
dc.publisher Royal Society of Chemistry en_US
dc.title Small molecule-mediated induction of endoplasmic reticulum stress in cancer cells en_US
dc.type Article en_US
dc.relation.journal RSC Medicinal Chemistry

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