COVID-19 pandemic: insights into molecular mechanisms leading to sex-based differences in patient outcomes

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dc.contributor.author Kumar, Ashutosh
dc.contributor.author Narayan, Ravi K.
dc.contributor.author Kulandhasamy, Maheswari
dc.contributor.author Prasoon, Pranav
dc.contributor.author Kumari, Chiman
dc.contributor.author Kumar, Sujeet
dc.contributor.author Pareek, Vikas
dc.contributor.author Sesham, Kishore
dc.contributor.author Shekhawat, Prakash S.
dc.contributor.author Kant, Kamla
dc.contributor.author Kumar, Santosh
dc.coverage.spatial United Kingdom
dc.date.accessioned 2012-09-29T14:45:09Z
dc.date.available 2012-09-29T14:45:09Z
dc.date.issued 2021-08
dc.identifier.citation Kumar, Ashutosh; Narayan, Ravi K.; Kulandhasamy, Maheswari; Prasoon, Pranav; Kumari, Chiman; Kumar, Sujeet; Pareek, Vikas; Sesham, Kishore; Shekhawat, Prakash S.; Kant, Kamla and Kumar, Santosh, "COVID-19 pandemic: insights into molecular mechanisms leading to sex-based differences in patient outcomes", Expert Reviews in Molecular Medicine, DOI: 10.1017/erm.2021.9, vol. 23, Aug. 2021. en_US
dc.identifier.issn 1462-3994
dc.identifier.uri https://doi.org/10.1017/erm.2021.9
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/6780
dc.description.abstract Recent epidemiological studies analysing sex-disaggregated patient data of coronavirus disease 2019 (COVID-19) across the world revealed a distinct sex bias in the disease morbidity as well as the mortality- both being higher for the men. Similar antecedents have been known for the previous viral infections, including from coronaviruses, such as severe acute respiratory syndrome (SARS) and middle-east respiratory syndrome (MERS). A sound understanding of molecular mechanisms leading to the biological sex bias in the survival outcomes of the patients in relation to COVID-19 will act as an essential requisite for developing a sex-differentiated approach for therapeutic management of this disease. Recent studies which have explored molecular mechanism(s) behind sex-based differences in COVID-19 pathogenesis are scarce; however, existing evidence, for other respiratory viral infections, viz. SARS, MERS and influenza, provides important clues in this regard. In attempt to consolidate the available knowledge on this issue, we conducted a systematic review of the existing empirical knowledge and recent experimental studies following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The qualitative analysis of the collected data unravelled multiple molecular mechanisms, such as evolutionary and genetic/epigenetic factors, sex-linkage of viral host cell entry receptor and immune response genes, sex hormone and gut microbiome-mediated immune-modulation, as the possible key reasons for the sex-based differences in patient outcomes in COVID-19.
dc.description.statementofresponsibility by Ashutosh Kumar, Ravi K. Narayan, Maheswari Kulandhasamy, Pranav Prasoon, Chiman Kumari, Sujeet Kumar, Vikas Pareek, Kishore Sesham, Prakash S. Shekhawat, Kamla Kant and Santosh Kumar
dc.format.extent vol. 23
dc.language.iso en_US en_US
dc.publisher Cambridge University Press en_US
dc.subject COVID-19 en_US
dc.subject Epigenetic mechanisms en_US
dc.subject Evolution en_US
dc.subject Genetics en_US
dc.subject SARS-CoV-2 en_US
dc.subject Sex en_US
dc.subject Sex hormones en_US
dc.title COVID-19 pandemic: insights into molecular mechanisms leading to sex-based differences in patient outcomes en_US
dc.type Article en_US
dc.relation.journal Expert Reviews in Molecular Medicine


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