Air-filled microbubbles based on albumin functionalized with gold nanocages and zinc phthalocyanine for multimodal imaging

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dc.contributor.author Maksimova, Elizaveta A.
dc.contributor.author Barmin, Roman A.
dc.contributor.author Rudakovskaya, Polina G.
dc.contributor.author Sindeeva, Olga A.
dc.contributor.author Prikhozhdenko, Ekaterina S.
dc.contributor.author Yashchenok, Alexey M.
dc.contributor.author Khlebtsov, Boris N.
dc.contributor.author Solovev, Alexander A.
dc.contributor.author Huang, Gaoshan
dc.contributor.author Mei, Yongfeng
dc.contributor.author Dey, Krishna Kanti
dc.contributor.author Gorin, Dmitry A.
dc.coverage.spatial Switzerland
dc.date.accessioned 2021-10-08T05:30:46Z
dc.date.available 2021-10-08T05:30:46Z
dc.date.issued 2021-09
dc.identifier.citation Maksimova, Elizaveta A.; Barmin, Roman A.; Rudakovskaya, Polina G.; Sindeeva, Olga A.; Prikhozhdenko, Ekaterina S.; Yashchenok, Alexey M.; Khlebtsov, Boris N.; Solovev, Alexander A.; Huang, Gaoshan; Mei, Yongfeng; Dey, Krishna Kanti and Gorin, Dmitry A., "Air-filled microbubbles based on albumin functionalized with gold nanocages and zinc phthalocyanine for multimodal imaging", Micromachines, DOI: 10.3390/mi12101161, vol. 12, no. 10, Sep. 2021. en_US
dc.identifier.issn 2072-666X
dc.identifier.uri https://doi.org/10.3390/mi12101161
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/6950
dc.description.abstract Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications
dc.description.statementofresponsibility by Elizaveta A. Maksimova, Roman A. Barmin, Polina G. Rudakovskaya, Olga A. Sindeeva, Ekaterina S. Prikhozhdenko, Alexey M. Yashchenok, Boris N. Khlebtsov, Alexander A. Solovev, Gaoshan Huang, Yongfeng Mei, Krishna Kanti Dey and Dmitry A. Gorin
dc.format.extent vol. 12, no. 10
dc.language.iso en_US en_US
dc.publisher MDPI en_US
dc.subject Microbubbles en_US
dc.subject Bovine serum albumin en_US
dc.subject Gold nanocages en_US
dc.subject Zinc phthalocyanine en_US
dc.subject Ultrasound imaging en_US
dc.subject Fluorescence tomography en_US
dc.subject Optoacoustic imaging en_US
dc.subject Multimodal imaging en_US
dc.title Air-filled microbubbles based on albumin functionalized with gold nanocages and zinc phthalocyanine for multimodal imaging en_US
dc.type Article en_US
dc.relation.journal Micromachines


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