Programmable, self-assembled DNA nanodevices for cellular programming and tissue engineering

Show simple item record Gangrade, Ankit Stephanopoulos, Nicholas Bhatia, Dhiraj
dc.coverage.spatial United Kingdom 2021-10-28T10:20:06Z 2021-10-28T10:20:06Z 2021-09
dc.identifier.citation Gangrade, Ankit; Stephanopoulos, Nicholas and Bhatia, Dhiraj, "Programmable, self-assembled DNA nanodevices for cellular programming and tissue engineering", Nanoscale, DOI: 10.1039/D1NR04475C, vol. 13, no. 40, pp. 16834-16846, Sep. 2021. en_US
dc.identifier.issn 2040-3364
dc.identifier.issn 2040-3372
dc.description.abstract DNA-based nanotechnology has evolved into an autonomous, highly innovative, and dynamic field of research at the nexus of supramolecular chemistry, nanotechnology, materials science, and biotechnology. DNA-based materials, including origami nanodevices, have started to emerge as an ideal scaffold for use in cellular programming, tissue engineering, and drug delivery applications. We cover herein the applications for DNA as a scaffold for interfacing with, and guiding, the activity of biological systems like cellsand tissues. Although DNA is a highly programmable molecular building block, it suffers from a lack of functional capacity for guiding and modulating cells. Coupling DNA to biologically active molecules can bestow bioactivity to these nanodevices. The main goal of such nanodevices is to synthesize systems that can bind to cells and mimic the extracellular environment, and serve as a highly promising toolbox for multiple applications in cellular programming and tissue engineering. DNA-based programmable devices offer a highly promising approach for programming collections of cells, tissue engineering, and regenerative medicine applications.
dc.description.statementofresponsibility by Ankit Gangrade, Nicholas Stephanopoulos and Dhiraj Bhatia
dc.format.extent vol. 13, no. 40, pp. 16834-16846
dc.language.iso en_US en_US
dc.publisher Royal Society of Chemistry en_US
dc.subject DNA-based nanotechnology en_US
dc.subject DNA en_US
dc.subject Bioengineering en_US
dc.subject Programmable molecule en_US
dc.subject Tissue engineering en_US
dc.title Programmable, self-assembled DNA nanodevices for cellular programming and tissue engineering en_US
dc.type Article en_US
dc.relation.journal Nanoscale

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