Feasibility of cerebellar transcranial direct current stimulation to facilitate goal-directed weight shifting in chronic post-stroke hemiplegics

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dc.contributor.author Ranjan, Shashi
dc.contributor.author Rezaee, Zeynab
dc.contributor.author Dutta, Anirban
dc.contributor.author Lahiri, Uttama
dc.coverage.spatial United States of America
dc.date.accessioned 2021-11-12T05:26:09Z
dc.date.available 2021-11-12T05:26:09Z
dc.date.issued 2021-10
dc.identifier.citation Ranjan, Shashi; Rezaee, Zeynab; Dutta, Anirban and Lahiri, Uttama, "Feasibility of cerebellar transcranial direct current stimulation to facilitate goal-directed weight shifting in chronic post-stroke hemiplegics", IEEE Transactions on Neural Systems and Rehabilitation Engineering, DOI: 10.1109/TNSRE.2021.3122202, vol. 29, pp. 2203-2210, Oct. 2021. en_US
dc.identifier.issn 1534-4320
dc.identifier.issn 1558-0210
dc.identifier.uri https://doi.org/10.1109/TNSRE.2021.3122202
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/7269
dc.description.abstract Neurological disorder such as stroke can adversely affect one’s weight-bearing symmetry leading to dysfunctional postural control. Recovery after stroke is facilitated through functionally-relevant neuroplastic modulation. Functionally-relevant cerebellum coordinates voluntary movements. Specifically, the dentate nuclei and lower limb representations (lobules VII-IX) of the cerebellum are involved in error-correction, crucial for postural control. It is postulated that cerebellar transcranial direct current stimulation (ctDCS) of the dentate nuclei and lobules VII-IX can modulate postural control in chronic stroke survivors. The objectives of this work were to (1) present a refined Virtual Reality (VR)-based balance training platform (VBaT) that can measure Center of Pressure (CoP) and (2) carry out a study to understand the implication of ctDCS stimulating the dentate nuclei (Phase D ) and lobules VII-IX (Phase L ) on the postural control of chronic stroke patients when they interacted with VBaT. Also, we investigated whether hemiplegic patients (with intact cerebellum) having Basal Ganglia (BG) infarction had any differential abilities to correct postural sway from those with no BG infarction (while shifting weight to the Affected side). Results of a single-session single-blind crossover study on randomized Phase D and Phase L stimulation (with an intermediate resting state bipolar bilateral ctDCS) on 12 chronic hemiplegic patients on separate days indicated differentiated findings (post stimulation) on CoP-related indices. We observed an incremental effect on one’s postural control during Phase D and inhibitory effect on the dentate nuclei during Phase L . Clustering analysis showed that those with BG infarction demonstrated poor postural control and deficit in error correction ability irrespective of the ctDCS Phase.
dc.description.statementofresponsibility by Shashi Ranjan, Zeynab Rezaee, Anirban Dutta and Uttama Lahiri
dc.format.extent vol. 29, pp. 2203-2210
dc.language.iso en_US en_US
dc.publisher Institute of Electrical and Electronics Engineers en_US
dc.subject Neurological disorder en_US
dc.subject Virtual Reality (VR)-based balance training platform (VBaT) en_US
dc.subject Basal Ganglia (BG) en_US
dc.subject Center of Pressure (CoP) en_US
dc.title Feasibility of cerebellar transcranial direct current stimulation to facilitate goal-directed weight shifting in chronic post-stroke hemiplegics en_US
dc.type Article en_US
dc.relation.journal IEEE Transactions on Neural Systems and Rehabilitation Engineering


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