COVID-19 Mechanisms in the human body�what we know so far

Show simple item record Kumar, Ashutosh Narayan, Ravi K. Prasoon, Pranav Kumari, Chiman Kaur, Gurjot Kumar, Santosh Kulandhasamy, Maheswari Sesham, Kishore Pareek, Vikas Faiq, Muneeb A. Pandey, Sada N. Singh, Himanshu N. Kant, Kamla Shekhawat, Prakash S. Raza, Khursheed Kumar, Sujeet
dc.coverage.spatial Switzerland 2021-12-01T13:18:11Z 2021-12-01T13:18:11Z 2021-11
dc.identifier.citation Kumar, Ashutosh; Narayan, Ravi K.; Prasoon, Pranav; Kumari, Chiman; Kaur, Gurjot; Kumar, Santosh; Kulandhasamy, Maheswari; Sesham, Kishore; Pareek, Vikas; Faiq, Muneeb A.; Pandey, Sada N.; Singh, Himanshu N.; Kant, Kamla; Shekhawat, Prakash S.; Raza, Khursheed and Kumar, Sujeet, "COVID-19 Mechanisms in the human body�what we know so far", Frontiers in Immunology, DOI: 10.3389/fimmu.2021.693938, vol. 12, Nov. 2021 en_US
dc.identifier.issn 1664-3224
dc.description.abstract More than one and a half years have elapsed since the commencement of the coronavirus disease 2019 (COVID-19) pandemic, and the world is struggling to contain it. Being caused by a previously unknown virus, in the initial period, there had been an extreme paucity of knowledge about the disease mechanisms, which hampered preventive and therapeutic measures against COVID-19. In an endeavor to understand the pathogenic mechanisms, extensive experimental studies have been conducted across the globe involving cell culture-based experiments, human tissue organoids, and animal models, targeted to various aspects of the disease, viz., viral properties, tissue tropism and organ-specific pathogenesis, involvement of physiological systems, and the human immune response against the infection. The vastly accumulated scientific knowledge on all aspects of COVID-19 has currently changed the scenario from great despair to hope. Even though spectacular progress has been made in all of these aspects, multiple knowledge gaps are remaining that need to be addressed in future studies. Moreover, multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have emerged across the globe since the onset of the first COVID-19 wave, with seemingly greater transmissibility/virulence and immune escape capabilities than the wild-type strain. In this review, we narrate the progress made since the commencement of the pandemic regarding the knowledge on COVID-19 mechanisms in the human body, including virus�host interactions, pulmonary and other systemic manifestations, immunological dysregulations, complications, host-specific vulnerability, and long-term health consequences in the survivors. Additionally, we provide a brief review of the current evidence explaining molecular mechanisms imparting greater transmissibility and virulence and immune escape capabilities to the emerging SARS-CoV-2 variants
dc.description.statementofresponsibility by Ashutosh Kumar, Ravi K. Narayan, Pranav Prasoon, Chiman Kumari, Gurjot Kaur, Santosh Kumar, Maheswari Kulandhasamy, Kishore Sesham, Vikas Pareek, Muneeb A. Faiq, Sada N. Pandey, Himanshu N. Singh, Kamla Kant, Prakash S. Shekhawat, Khursheed Raza and Sujeet Kumar
dc.format.extent vol. 12
dc.language.iso en_US en_US
dc.publisher Frontiers Media en_US
dc.subject COVID-19 en_US
dc.subject SARS-CoV-2 en_US
dc.subject Immune system en_US
dc.subject Viral properties en_US
dc.subject Tissue tropism en_US
dc.title COVID-19 Mechanisms in the human body�what we know so far en_US
dc.type Article en_US
dc.relation.journal Frontiers in Immunology

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