Histotripsy bubble cloud contrast with chirp-coded excitation in preclinical models

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dc.contributor.author Wallach, Emily L.
dc.contributor.author Shekhar, Himanshu
dc.contributor.author Flores-Guzman, Fernando
dc.contributor.author Hernandez, Sonia L.
dc.contributor.author Bader, Kenneth B.
dc.coverage.spatial United States of America
dc.date.accessioned 2022-02-11T08:02:49Z
dc.date.available 2022-02-11T08:02:49Z
dc.date.issued 2022-02
dc.identifier.citation Wallach, Emily L.; Shekhar, Himanshu; Flores-Guzman, Fernando; Hernandez, Sonia L. and Bader, Kenneth B., "Histotripsy bubble cloud contrast with chirp-coded excitation in preclinical models", IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, DOI: 10.1109/TUFFC.2021.3125922, vol. 69, no. 2, pp. 787-794, Feb. 2022. en_US
dc.identifier.issn 0885-3010
dc.identifier.issn 1525-8955
dc.identifier.uri https://doi.org/10.1109/TUFFC.2021.3125922
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/7509
dc.description.abstract Histotripsyis a focusedultrasoundtherapy for tissue ablation via the generation of bubble clouds. These effects can be achieved noninvasively,making sensitive and specific bubble imaging essential for histotripsy guidance. Plane-wave ultrasound imaging can track bubble clouds with an excellent temporal resolution, but there is a significant reduction in echoes when deep-seated organs are targeted. Chirp-codedexcitationuses wideband, long-duration imaging pulses to increase signals at depth and promote nonlinear bubble oscillations. In this study, we evaluated histotripsy bubble contrast with chirp-coded excitation in scattering gel phantoms and a subcutaneous mouse tumor model. A range of imaging pulse durations were tested, and compared to a standard plane-wave pulse sequence. Received chirped signals were processed with matched filters to highlight components associatedwith either fundamental or subharmonic (bubble-specific) frequency bands. The contrast-to-tissue ratio (CTR) was improved in scattering media for subharmonic contrast relative to fundamental contrast (both chirped and standard imaging pulses) with the longest-duration chirped-pulse tested (7.4 μs pulse duration). The CTR was improved for subharmonic contrast relative to fundamental contrast (both chirped and standard imaging pulses) by 4.25 dB ± 1.36 dB in phantoms and 3.84 dB ± 6.42 dB in vivo. No systematic changes were observed in the bubble cloud size or dissolution rate between sequences, indicating image resolution was maintained with the long-duration imaging pulses. Overall, this study demonstrates the feasibility of specific histotripsy bubble cloud visualization with chirp-coded excitation.
dc.description.statementofresponsibility by Emily L. Wallach, Himanshu Shekhar, Fernando Flores-Guzman, Sonia L. Hernandez and Kenneth B. Bader
dc.format.extent vol. 69, no. 2, pp. 787-794
dc.language.iso en_US en_US
dc.publisher Institute of Electrical and Electronics Engineers en_US
dc.subject Biomedical acoustics en_US
dc.subject Cavitation en_US
dc.subject High frame rate imaging en_US
dc.subject Histotripsy en_US
dc.subject Mouse Tumor Mode en_US
dc.title Histotripsy bubble cloud contrast with chirp-coded excitation in preclinical models en_US
dc.type Article en_US
dc.relation.journal IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control


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