Co-delivery nanosystem of epigallocatechin gallate and rutin for anticancer and antibacterial activities

Show simple item record Saha, Sarmistha Prajapati, Deepak Ratrey, Poonam Mishra, Abhijit
dc.coverage.spatial United States of America 2022-03-10T14:08:58Z 2022-03-10T14:08:58Z 2022-04
dc.identifier.citation Saha, Sarmistha; Prajapati, Deepak; Ratrey, Poonam and Mishra, Abhijit, "Co-delivery nanosystem of epigallocatechin gallate and rutin for anticancer and antibacterial activities", Journal of Drug Delivery Science and Technology, DOI: 10.1016/j.jddst.2022.103191, vol. 70, Apr. 2022. en_US
dc.identifier.issn 1773-2247
dc.description.abstract Although chemotherapy has successfully treated cancer to some extent, high doses, multiple drug resistance, undesirable toxic effects, and non-selective targeting are the major pitfalls. Nano drug materials have emerged as a promising method to improve the therapeutic benefit for extremely hydrophobic drugs, and nano-based combination therapy can potentially target these challenges. Here, an amphiphilic PEG-PCL diblock copolymer co-encapsulated with epigallocatechin-3-gallate and rutin nanorods within the range of 110 ± 15 nm and 26 ± 5.3 nm in length and width was developed as a combination therapy that synergistically combines features of anticancer and antibacterial activities. The drug release kinetics revealed that drug release from nanorods is due to anomalous diffusion with 77% of EGCG and 62% of rutin at lower pH 5.0 for a time period of 24 h. In vitro cytotoxicity assays against A549 human lung adenocarcinoma and HeLa cervical cancer cell lines showed that nanorods have a concentration-dependent synergistic effect in inducing intracellular reactive oxygen species (ROS) generation and cancer cell apoptosis by the up-regulation of caspase 9/3 activities. Confocal laser scanning microscopy further confirmed the potential internalization of nanorods into the cancer cells. Also, nanorods showed antibacterial effects against E. coli and S. aureus strains by cell membrane damage confirmed by time-killing kinetic studies and SEM analysis. Besides, hemolytic studies showed the biocompatibility of nanorods with human red blood cells. These findings hold promise for engineering multifunctional nanorods-based co-delivery systems targeting cancer and bacterial infections.
dc.description.statementofresponsibility by Sarmistha Saha, Deepak Prajapati, Poonam Ratrey and Abhijit Mishra
dc.format.extent vol. 70
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Nanorods en_US
dc.subject Epigallocatechin-3-gallate en_US
dc.subject Rutin en_US
dc.subject PEG-PCL polymer en_US
dc.subject Anticancer en_US
dc.subject Antibacterial en_US
dc.title Co-delivery nanosystem of epigallocatechin gallate and rutin for anticancer and antibacterial activities en_US
dc.type Article en_US
dc.relation.journal Journal of Drug Delivery Science and Technology

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