Metabolic engineering for enhanced hydrogen production: a review

Show simple item record Goyal, Yogesh Kumar, Manish Gayen, Kalyan 2014-03-16T11:49:02Z 2014-03-16T11:49:02Z 2012-11
dc.identifier.citation Goyal, Yogesh; Kumar, Manish and Gayen, Kalyan, “Metabolic engineering for enhanced hydrogen production: A review”, Canadian Journal of Microbiology, DOI: 10.1139/cjm-2012-0494, vol. 59, no. 2, pp.59-78, Nov. 2012. en_US
dc.identifier.issn 0008-4166
dc.description.abstract Hydrogen gas exhibits potential as a sustainable fuel for the future. Therefore, many attempts have been made with the aim of producing high yields of hydrogen gas through renewable biological routes. Engineering of strains to enhance the production of hydrogen gas has been an active area of research for the past 2 decades. This includes overexpression of hydrogen-producing genes (native and heterologous), knockout of competitive pathways, creation of a new productive pathway, and creation of dual systems. Interestingly, genetic mutations in 2 different strains of the same species may not yield similar results. Similarly, 2 different studies on hydrogen productivities may differ largely for the same mutation and on the same species. Consequently, here we analyzed the effect of various genetic modifications on several species, considering a wide range of published data on hydrogen biosynthesis. This article includes a comprehensive metabolic engineering analysis of hydrogen-producing organisms, namely Escherichia coli, Clostridium, and Enterobacter species, and in addition, a short discussion on thermophilic and halophilic organisms. Also, apart from single-culture utilization, dual systems of various organisms and associated developments have been discussed, which are considered potential future targets for economical hydrogen production. Additionally, an indirect contribution towards hydrogen production has been reviewed for associated species. en_US
dc.description.statementofresponsibility by Yogesh Goyal, Manish Kumar and Kalyan Gayen
dc.format.extent Vol. 59, No. 2, pp.59-78
dc.language.iso en en_US
dc.publisher NRC Research Press en_US
dc.subject Clostridium en_US
dc.subject Enterobacter en_US
dc.subject Escherichia coli en_US
dc.subject Dual systems en_US
dc.subject Hydrogen en_US
dc.subject Metabolic engineering en_US
dc.title Metabolic engineering for enhanced hydrogen production: a review en_US
dc.type Article en_US
dc.relation.journal Canadian Journal of Microbiology

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