Peptide functionalized DNA hydrogel enhances neuroblastoma cell growth and differentiation

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dc.contributor.author Hivare, Pravin
dc.contributor.author Gangrade, Ankit
dc.contributor.author Swarup, Gitanjali
dc.contributor.author Bhavsar, Krishna
dc.contributor.author Singh, Ankur
dc.contributor.author Gupta, Ratnika
dc.contributor.author Thareja, Prachi
dc.contributor.author Gupta, Sharad
dc.contributor.author Bhatia, Dhiraj
dc.coverage.spatial United Kingdom
dc.date.accessioned 2022-06-29T12:39:33Z
dc.date.available 2022-06-29T12:39:33Z
dc.date.issued 2022-05
dc.identifier.citation Hivare, Pravin; Gangrade, Ankit; Swarup, Gitanjali; Bhavsar, Krishna; Singh, Ankur; Gupta, Ratnika; Thareja, Prachi; Gupta, Sharad and Bhatia, Dhiraj, "Peptide functionalized DNA hydrogel enhances neuroblastoma cell growth and differentiation", Nanoscale, DOI: 10.1039/d1nr07187d, vol. 14, no. 24, pp. 8611-8620, May 2022. en_US
dc.identifier.issn 2040-3364
dc.identifier.issn 2040-3372
dc.identifier.uri https://doi.org/10.1039/d1nr07187d
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/7834
dc.description.abstract Designing programmable biomaterials that could act as extracellular matrices and permit functionalization is a current need for tissue engineering advancement. DNA based hydrogels are gaining significant attention owing to their self-assembling properties, biocompatibility, chemical robustness and low batch to batch variability. The real potential of DNA hydrogels in the biomedical domain remains to be explored. In this work, a DNA hydrogel was coated on a glass surface and coupled to a synthetic IKVAV peptide by a chemical crosslinker. We observe enhanced neuronal differentiation, prolonged neurite length, dynamic movement of microtubules and cytoskeleton, and altered endocytic mechanisms in neuroblastoma-based stem cells for the peptide modified DNA hydrogel compared to the unmodified DNA hydrogel and controls. We anticipate that a peptide-modified DNA hydrogel could emerge as a promising scaffold coating material to develop nerve tissue conduits in the future for application in neuroscience and neuroregeneration.
dc.description.statementofresponsibility by Pravin Hivare, Ankit Gangrade, Gitanjali Swarup, Krishna Bhavsar, Ankur Singh, Ratnika Gupta, Prachi Thareja, Sharad Gupta and Dhiraj Bhatia
dc.language.iso en_US en_US
dc.publisher Royal Society of Chemistry en_US
dc.subject Biomaterials en_US
dc.subject Extracellular en_US
dc.subject Hydrogels en_US
dc.subject Biocompatibility en_US
dc.subject IKVAV peptide en_US
dc.subject Cytoskeleton en_US
dc.title Peptide functionalized DNA hydrogel enhances neuroblastoma cell growth and differentiation en_US
dc.type Article en_US
dc.relation.journal Nanoscale


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