An efficient protocol for the synthesis of novel hetero-aryl chalcone: a versatile synthon for several heterocyclic scaffolds and sensors

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dc.contributor.author Tandel, Shivani
dc.contributor.author Patel, Nilam C.
dc.contributor.author Kanvah, Sriram
dc.contributor.author Patel, Paresh N.
dc.coverage.spatial United States of America
dc.date.accessioned 2022-08-02T14:47:38Z
dc.date.available 2022-08-02T14:47:38Z
dc.date.issued 2022-12
dc.identifier.citation Tandel, Shivani; Patel, Nilam C.; Kanvah, Sriram and Patel, Paresh N., “An efficient protocol for the synthesis of novel hetero-aryl chalcone: a versatile synthon for several heterocyclic scaffolds and sensors”, Journal of Molecular Structure, DOI: 10.1016/j.molstruc.2022.133808, vol. 1269, Dec. 2022. en_US
dc.identifier.issn 0022-2860
dc.identifier.uri https://doi.org/10.1016/j.molstruc.2022.133808
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/7951
dc.description.abstract Chalcone is a resourceful scaffold of various biologically active heteroaryl derivatives. Several protocols, name reactions, and natural processes are known for synthesizing multiple chalcone derivatives. Herein we report a comparative study to synthesize novel heteroaryl chalcone derivatives. The designed chalcone scaffolds are synthesized by a reaction of substituted aromatic ketones and benzo[b]thiophene carbaldehyde in the presence of the catalytic amount of KOH or cost-effective pyrrolidine catalyst under room temperature. The pyrrolidine catalysed process gave better synthetic yields but slower than the KOH catalysed process. All the newly synthesized molecular structures are confirmed using IR, NMR, and HRMS. The stereochemistry of the synthesized compounds is established using single-crystal XRD structures. The synthesized chalcone was also used for the sensing of hydrazine.
dc.description.statementofresponsibility by Shivani Tandel, Nilam C. Patel, Sriram Kanvah and Paresh N. Patel
dc.format.extent vol. 1269
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Chalcone en_US
dc.subject Benzothiophene en_US
dc.subject Single crystal XRD en_US
dc.subject Hydrazine en_US
dc.subject HRMS en_US
dc.subject NMR en_US
dc.title An efficient protocol for the synthesis of novel hetero-aryl chalcone: a versatile synthon for several heterocyclic scaffolds and sensors en_US
dc.type Article en_US
dc.relation.journal Journal of Molecular Structure


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