Metabolic network analysis of biobutanol production using Clostridium acetobutylicum

Show simple item record

dc.contributor.author Kumar, Manish
dc.contributor.author Gayen, Kalyan
dc.contributor.other Chemcon-2010 (Indian Chemical Engineering Congress), 63rd Annual Session of Indian Institute of Chemical Engineers at Annamalai University
dc.coverage.spatial Tamil Nadu, India
dc.date.accessioned 2014-04-22T13:48:55Z
dc.date.available 2014-04-22T13:48:55Z
dc.date.issued 2010-12-27
dc.identifier.citation Kumar, M. and Gayen, Kalyan, “Metabolic network analysis of biobutanol production using Clostridium acetobutylicum”, Chemcon-2010 (Indian Chemical Engineering Congress), 63rd Annual Session of Indian Institute of Chemical Engineers at Annamalai University, IN, December 27-29, 2010. en_US
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1024
dc.description.abstract Biofuel production from renewable resources is being demanded due to petroleum dependency and continuous depletion of petroleum oil reservoirs. After knowing the applications of biobutanol as biofuel, its economical production is the challenge for researchers. There is two phased (acidogenesis and solventogenesis) metabolism network of Clostridium acetobutylicum has been studied. It is believed that solventogenesis phase of Clostridium acetobutylicum metabolism is key phase in biobutanol production. During solventogenesis, butanol, ethanol, and acetone are produced in acetone-butanol-ethanol (ABE) fermentation and bacteria uptake the acids (butyrate and acetate) produced in acidogenesis phase. Additionally, ethanol can be produced separately from butanol and acetone and with lowest yield. The uptake of acids and the formation of acetone are coupled and there cannot be any uptake of acetate and butyrate without the formation of an equivalent amount of acetone. We have performed metabolic network analysis of this organism using elementary mode analysis. Metabolic network analysis suggests that butanol synthesis is always coupled with acetone production. The gene, namely acetoacetate decarboxylase (adc) is responsible for the synthesis of acetone producing enzymes which can be engineered to enhance butanol production. We also studied the optimal solution space for biobutanol production which will help to understand the optimal feeding strategy semi-batch fermentation process. en_US
dc.description.statementofresponsibility by M. Kumar and Kalyan Gayen
dc.language.iso en en_US
dc.subject Acetobutylicum en_US
dc.subject Acidogenesis en_US
dc.subject Biofuel production en_US
dc.subject Metabolic Network en_US
dc.subject Solventogenesis en_US
dc.title Metabolic network analysis of biobutanol production using Clostridium acetobutylicum en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account