Passivation of high surface energy sites of milled ibuprofen Crystals via Dry Coating

Show simple item record Han, Xi Jallo, Laila J. To, Daniel Ghoroi, Chinmay Dave, Rajesh N.
dc.contributor.other AAPS Annual Meeting and Exposition
dc.coverage.spatial McCormick Place, Chicago, US 2014-04-23T16:49:57Z 2014-04-23T16:49:57Z 2012-10-08
dc.identifier.citation Ghoroi, Chinmay et al., “Passivation of high surface energy sites of milled ibuprofen Crystals via Dry Coating”, in AAPS Annual Meeting and Exposition, McCormick Place, Chicago, US, October 14-18, 2012. en_US
dc.description.abstract Ibuprofen micronization with dry coating is investigated to examine its influence on passivation/stabilization of high-surface-energy sites and reduced cohesion. A fluid energy mill was used to micronize ibuprofen particles down to 5–28 μm with or without simultaneous nanosilica coating. Powder flow property and dispersibility were characterized using FT4 powder tester and Rodos/Helos laser diffraction particle sizer. Surface energy was characterized using a next generation inverse gas chromatography instrument. Uncoated micronized ibuprofen showed an increased Lifshitz–van der Waals (LW) dispersion component of surface energy with increasing milling intensity. In contrast, dry-coated milled powders showed a significant reduction in the LW component, whereas physical mixture of uncoated micronized ibuprofen and silica exhibited no reduction in surface energy, indicating that dry coating is necessary for the passivation of high-energy sites of ibuprofen created during micronization. Surface energy of pure micronized ibuprofen was highly heterogeneous, whereas dry-coated ibuprofen had greatly reduced heterogeneity. Micronization with dry coating also improved flowability and bulk density as compared with pure active pharmaceutical ingredient micronization without coating, or just blending with silica. Overall, dry coating leads to decreased cohesion and improved flowability because of reduced LW dispersive component of surface energy and creating nanoscale surface roughness. en_US
dc.description.statementofresponsibility by Xi Han, Laila J. Jallo, Daniel To, Chinmay Ghoroi and Rajesh N. Dave
dc.format.extent vol. 102, no. 7, pp. 2282-2296
dc.language.iso en en_US
dc.subject Dry particle coating en_US
dc.subject Formulation en_US
dc.subject Inverse gas chromatography en_US
dc.subject Milling en_US
dc.subject Powder technology en_US
dc.subject Solid state en_US
dc.subject Surface chemistry en_US
dc.subject Surface energy heterogeneity en_US
dc.title Passivation of high surface energy sites of milled ibuprofen Crystals via Dry Coating en_US
dc.type Article en_US

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