Elementary mode analysis reveals that Clostridium acetobutylicum modulates its metabolic strategy under external stress

Show simple item record

dc.contributor.author Kumar, Manish
dc.contributor.author Gayen, Kalyan
dc.contributor.author Saini, Supreet
dc.date.accessioned 2014-06-26T05:31:59Z
dc.date.available 2014-06-26T05:31:59Z
dc.date.issued 2014-05
dc.identifier.citation Kumar, Manish; Gayen, Kalyan and Saini, Supreet, "Elementary mode analysis reveals that Clostridium acetobutylicum modulates its metabolic strategy under external stress", Molecular BioSystems, DOI: 10.1039/C4MB00126E, May 2014. en_US
dc.identifier.issn 1742-206X
dc.identifier.uri http://dx.doi.org/10.1039/C4MB00126E
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1319
dc.description.abstract Clostridium acetobutylicum is a strict anaerobe which exhibits two distinct steps in its metabolic network. In the first step, sugars are oxidized to organic acids (acetic and butyric). This is accompanied with growth. The acids produced in the first phase are re-assimilated into solvents (acetone, butanol, and ethanol) in the second phase of metabolism. The two phases are hence called acidogenesis and solventogenesis, respectively. In this work, using Elementary Mode Analysis (EMA), we quantify fluxes through Elementary Modes under different physical and chemical conditions. Our analysis reveals that, in response to external stresses, the organism invokes Elementary Modes which couple acidogenesis and solventogenesis. This coupling leads to the organism exhibiting characteristics of both, acidogenesis and solventogenesis at the same time. Significantly, this coupling was not invoked during any “unstressed” conditions tested in this study. Overall, our work highlights the flexibility in Clostridium acetobutylicum to modulate its metabolism to enhance chances of survival under harsh conditions en_US
dc.description.statementofresponsibility by Manish Kumar, Kalyan Gayen and Supreet Saini
dc.format.extent vol. 10, no. 8, pp. 2090-2105
dc.language.iso en en_US
dc.publisher Royal Society of Chemistry en_US
dc.subject Acetic and butyric en_US
dc.subject Acetone, Butanol, and Ethanol en_US
dc.subject Clostridium acetobutylicum en_US
dc.title Elementary mode analysis reveals that Clostridium acetobutylicum modulates its metabolic strategy under external stress en_US
dc.type Article en_US
dc.relation.journal Molecular BioSystems


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


Browse

My Account