Fine powder flow under humid environmental conditions from the perspective of surface energy

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dc.contributor.author Karde, Vikram
dc.contributor.author Ghoroi, Chinmay
dc.date.accessioned 2015-03-25T11:56:15Z
dc.date.available 2015-03-25T11:56:15Z
dc.date.issued 2015-05
dc.identifier.citation Karde, Vikram and Ghoroi, Chinmay, “Fine powder flow under humid environmental conditions from the perspective of surface energy”, International Journal of Pharmaceutics, DOI: 10.1016/j.ijpharm.2015.03.021, vol. 485, no. 1-2, pp. 192-201, May. 2015. en_US
dc.identifier.issn 0378-5173
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1651
dc.identifier.uri http://dx.doi.org/10.1016/j.ijpharm.2015.03.021
dc.description.abstract The influence of humidity on surface energetics and flow behavior of fine pharmaceutical powders was investigated. Amorphous and crystalline fine powders with hydrophilic (Corn starch and Avicel PH105) and hydrophobic (ibuprofen) nature were considered for this study. The surface energy was determined using surface energy analyzer and flow behavior was measured in terms of unconfined yield stress (UYS) using a shear tester. The study showed that unlike hydrophobic ibuprofen powder, surface energy and flow of hydrophilic excipient powders were affected by relative humidity (RH). The Lifshitz–van der Waals dispersive (γLW) component of surface energy barely changed with varying RH for all pharmaceutical powders. For hydrophilic excipients, the specific component of surface energy (γSP) was found to increase with increasing RH. Furthermore, for these excipients, flow deterioration at elevated RH was observed due to increased capillary bridge formation. Detailed analysis showed that γSP component of surface energy can be an effective indicator for flow behavior of fine powders under varying humid conditions. The present study also brought out the existence of different regimes of probable interparticle forces which dictate the bulk flow behavior of fine hydrophilic powder under humid conditions. en_US
dc.description.statementofresponsibility by Vikram Karde and Chinmay Ghoroi
dc.format.extent Vol. 485, No. 1-2, pp. 192–201
dc.language.iso en en_US
dc.publisher Science Direct en_US
dc.subject Humidity en_US
dc.subject Interparticle force en_US
dc.subject Moisture sorption en_US
dc.subject Pharmaceutical powders en_US
dc.subject Powder flow en_US
dc.subject Surface energy en_US
dc.title Fine powder flow under humid environmental conditions from the perspective of surface energy en_US
dc.type Article en_US
dc.relation.journal International Journal of Pharmaceutics


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