Effect of temperature on the surface free energy and acid–base properties of Gabapentin and Pregabalin drugs - a comparative study

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dc.contributor.author Ramanaiah, S.
dc.contributor.author Karde, Vikram
dc.contributor.author Venkateswarlu, P.
dc.contributor.author Ghoroi, Chinmay
dc.date.accessioned 2015-06-26T10:14:55Z
dc.date.accessioned 2015-06-26T10:15:02Z
dc.date.available 2015-06-26T10:14:55Z
dc.date.available 2015-06-26T10:15:02Z
dc.date.issued 2015-06
dc.identifier.citation Ramanaiah, S.; Karde, Vikram; Venkateswarlu, P. and Ghoroi, Chinmay, “Effect of temperature on the surface free energy and acid–base properties of Gabapentin and Pregabalin drugs - a comparative study”, RSC Advances, DOI: 10.1039/C5RA03032C, vol. 5, no. 60, pp. 48712-48719, Jun. 2015. en_US
dc.identifier.issn 2046-2069
dc.identifier.uri http://dx.doi.org/10.1039/C5RA03032C
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/1790
dc.description.abstract The surface energetics of Gabapentin (GBP) [2-[1-(aminomethyl) cyclohexyl] acetic acid] and Pregabalin (PGB) [(S)-3-(aminomethyl)-5-methylhexanoic acid] were studied using a surface energy analyzer (SEA); a new-generation inverse gas chromatography technique, in the temperature range of 298.15–323.15 K. The Lifshitz–van der Waals dispersive (γds) component of the surface energy was calculated using Schultz and Dorris-Gray methods. The specific free energy of adsorption (ΔGspa) and specific component of surface free energy (γsps) were determined using Schultz and Polarization methods. For both the drugs, the γds component of the surface energy was found to decrease with the increase in temperature. The γds component of the surface energy obtained for GBP and PGB surfaces suggested that GBP is slightly more energetically active than PGB. However, the PGB surface showed slightly higher γsps implying its more polar nature as compared to GBP. These drugs with different structures but identical functional groups (–NH2 and –COOH), were found to have a higher surface Lewis base parameter, (Kb), indicating predominately basic surfaces. Furthermore, the temperature dependence of the Lewis acid–base parameters for these drugs was attributed to the disruption of intramolecular hydrogen bonding at higher temperatures. en_US
dc.description.statementofresponsibility by S. Ramanaiah, Vikram Karde, P. Venkateswarlua and Chinmay Ghoroi
dc.format.extent vol. 5, no. 60, pp. 48712-48719
dc.language.iso en en_US
dc.publisher Royal Society of Chemistry en_US
dc.subject Chromatography en_US
dc.subject Lifshitz–van der Waals dispersive en_US
dc.subject Pregabalin en_US
dc.title Effect of temperature on the surface free energy and acid–base properties of Gabapentin and Pregabalin drugs - a comparative study en_US
dc.type Article en_US
dc.relation.journal RSC Advances


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