Understanding rationale behind carbamazepine co-crystallization with acids, amides and hydrazides

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dc.contributor.author Sathisaran, Indumathi
dc.contributor.author Dalvi, Sameer Vishvanath
dc.date.accessioned 2018-01-08T12:33:53Z
dc.date.available 2018-01-08T12:33:53Z
dc.date.issued 2017-08
dc.identifier.citation Sathisaran, Indumathi and Dalvi, Sameer Vishvanath, "Understanding rationale behind carbamazepine co-crystallization with acids, amides and hydrazides", Acta Crystallographica Section A, DOI: 10.1107/S2053273317091380, vol. 73, no. a2, pp. C435, Aug. 2017. (Abstract) en_US
dc.identifier.issn 2053-2733
dc.identifier.uri http://dx.doi.org/10.1107/S2053273317091380
dc.identifier.uri http://repository.iitgn.ac.in/handle/123456789/3380
dc.description.abstract Carbamazepine is an active pharmaceutical ingredient with anticonvulsive properties. Cocrystallization is of an API helps infine tuning its solid-state properties such as shelf life, melting point, solubility, dissolution and bioavailability. Cocrystallizationof carbamazepine with several structurally-related coformers belonging to class of amides and acids has been widely studiedtill date. However, an indepth understanding of rationale behind carbamazepine cocrystallization with acids or amides has notbeen exposed yet. Also, the potential of hydrazides to form cocrystals with carbamazepine has not been investigated yet. Inthis work, we propose to understand the rationale behind carbamazepine cocrystallization with different structurally relatedcoformers. Dicarboxylic acids (Pimelic acid, suberic acid, azelaic acid, sebacic acid), tricarboxylic acids (Trimellitic acid),carboxamides (acetamide, salicylamide and p-hydroxybenzamide) and hydrazides (niazid, isoniazid and maleic acid hydrazide)has been used as coformers for our study. The role of number of C atoms in dicarboxylic and tricarboxylic acids, theinfluence of aromatic rings present in amides and the influence of �R functional group in hydrazides in cocrystallizationprocess has been investigated in detail. Our experimental observations illustrated that some systems result in cocrystalswhereas some others result into eutectics or physical mixtures. Succinic acid tends to form cocrystals whereas suberic acidresulted in eutectic as a consequence. Similarly, benzamide resulted in cocrystal whereas acetamide resulted in a physicalmixture based on the DSC thermograms. An indepth understanding is being developed to identify the rationale responsiblefor cocrystallization with further characterization techniques. Hence, we suggest that conducting a thorough study tounderstand the rationale behind cocrystallization can be implemented to different drug systems which can further simplifythe cocrystal screening process for structurally-related drugs in a pharmaceutical industry.
dc.description.statementofresponsibility by Indumathi Sathisaran and Sameer V Dalvi
dc.format.extent vol. 73, no. a2, pp. C435
dc.language.iso en en_US
dc.publisher International Union of Crystallography en_US
dc.subject Carbamazepine en_US
dc.subject cocrystallization en_US
dc.subject understanding en_US
dc.title Understanding rationale behind carbamazepine co-crystallization with acids, amides and hydrazides en_US
dc.type Article en_US
dc.relation.journal Acta Crystallographica Section A


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