Understanding stability relationships among three curcumin polymorphs

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dc.contributor.author Pandey, Komal Upendra
dc.contributor.author Dalvi, Sameer V.
dc.date.accessioned 2018-12-01T05:10:35Z
dc.date.available 2018-12-01T05:10:35Z
dc.date.issued 2018-11
dc.identifier.citation Pandey, Komal Upendra and Dalvi, Sameer Vishvanath, "Understanding stability relationships among three curcumin polymorphs", Advanced Powder Technology, DOI: 10.1016/j.apt.2018.11.002, Nov. 2018. en_US
dc.identifier.issn 0921-8831
dc.identifier.uri https://doi.org/10.1016/j.apt.2018.11.002
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/4037
dc.description.abstract Understanding thermodynamic stability relationship among polymorphs of any active pharmaceutical ingredient (API) is a necessary step for drug formulation development. Knowledge of such relationship enables identification of a stable polymorphic form at the prevalent conditions. Curcumin, a pharmaceutically active ingredient found in herbal spice turmeric, exists in three polymorphic forms; a monoclinic form (Form 1) and two orthorhombic forms (Form 2 and Form 3). However, thermodynamic stability relationships among curcumin polymorphs have not been ascertained yet. This work therefore, was focused on understanding thermodynamic stability relationships among curcumin polymorphs. During purification of curcumin, the pressure applied for vacuum evaporation of organic solvent was found to significantly affect the polymorphic outcome. Form 1 was obtained at pressures ranging from 300 to 400 mbar whereas Form 2 was obtained at pressures ranging from 100 to 200 mbar. Form 3 was obtained by liquid antisolvent precipitation using ultrasound and Bovine Serum Albumin (BSA) as an additive. The obtained polymorphs were characterized by X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC) techniques. Relative stability of polymorphs was established by conducting solvent mediated transformation studies, thermal analysis through DSC and variable temperature X-ray diffraction studies (VT-XRD). It was observed that Form 2 and Form 3 irreversibly convert to Form 1 upon heating. Further, Form 2 and Form 3 convert to Form 1 in aqueous organic solutions at temperatures ranging from 0 °C to 50 °C. Thus, the curcumin polymorphs were found to be monotropically related to each other with the monoclinic form (Form 1) being the most stable form.
dc.description.statementofresponsibility by Komal Upendra Pandey and Sameer Vishvanath Dalvi
dc.format.extent vol. 30, no. 5, pp. 266-276
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Relative thermodynamic stability en_US
dc.subject Polymorphic transformation en_US
dc.subject Enantiotropy en_US
dc.subject Monotropy en_US
dc.subject Curcumin, monoclinic en_US
dc.subject Orthorhombic en_US
dc.title Understanding stability relationships among three curcumin polymorphs en_US
dc.type Article en_US
dc.relation.journal Advanced Powder Technology


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