Anionic carboxymethylagarose-based pH-responsive smart superabsorbent hydrogels for controlled release of anticancer drug

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dc.contributor.author Khana, Huma
dc.contributor.author Chaudhary, Jai Prakash
dc.contributor.author Meena, Ramavatar
dc.date.accessioned 2019-06-19T11:12:53Z
dc.date.available 2019-06-19T11:12:53Z
dc.date.issued 2019-03
dc.identifier.citation Khana, Huma; Chaudhary, Jai Prakash and Meena, Ramavatar, "Anionic carboxymethylagarose-based pH-responsive smart superabsorbent hydrogels for controlled release of anticancer drug", International Journal of Biological Macromolecules, DOI: 10.1016/j.ijbiomac.2018.12.045, vol. 124, pp. 1220-1229, Mar. 2019. en_US
dc.identifier.uri https://doi.org/10.1016/j.ijbiomac.2018.12.045
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/4455
dc.description.abstract Herein, we demonstrate the preparation of superabsorbent hydrogel (CMA-g-PAm) materials using anionic and cold water soluble carboxymethyagarose (CMA, a�seaweed�polysaccharide-based derivative) with polyacrylamide (PAm) through rapid microwave assisted grafting technique. The successful fabrication of CMA-g-PAm was verified by FT-IR, SEM, XRD, TGA and CHN analyzer. Effects of initiator, crosslinker, and monomer on the swelling behavior and grafting parameters have been thoroughly investigated. Moreover, the swelling behavior of the resulting hydrogels was systematically studied, and the results suggested they exhibit excellent pH and salt responsive behavior. The drug delivery application of thus fabricated hydrogel was further evaluated using�doxorubicin�(Dox) as a model drug to explore its possible applications. Release study results revealed that Dox release was significantly accelerated with decrease in pH from 7.4 to 5.0. Toxicity assays confirmed that the blank hydrogels had negligible toxicity to normal cells (VERO), whereas the Dox-loaded hydrogels remained high in cytotoxicity for A549 and Hep-G2�cancer cells. All of these attributes implied that the new proposed hydrogel (HK11) serves as potential drug delivery platforms for cancer therapy.
dc.description.statementofresponsibility by Huma Khana, Jai Prakash Chaudhary and Ramavatar Meena
dc.format.extent vol. 124, pp. 1220-1229
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Carboxymethylagarose en_US
dc.subject Functional polymers en_US
dc.subject Drug delivery en_US
dc.title Anionic carboxymethylagarose-based pH-responsive smart superabsorbent hydrogels for controlled release of anticancer drug en_US
dc.type Article en_US
dc.relation.journal International Journal of Biological Macromolecules


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