Environmental fate, distribution and state-of-the-art removal of antineoplastic drugs: a comprehensive insight

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dc.contributor.author Mukherjee, Santanu
dc.contributor.author Mehta, Dip
dc.contributor.author Dhangar, Kiran
dc.contributor.author Kumar, Manish
dc.date.accessioned 2020-11-05T06:07:17Z
dc.date.available 2020-11-05T06:07:17Z
dc.date.issued 2020-10
dc.identifier.citation Mukherjee, Santanu; Mehta, Dip; Dhangar, Kiran and Kumar, Manish, “Environmental fate, distribution and state-of-the-art removal of antineoplastic drugs: a comprehensive insight”, Chemical Engineering Journal, DOI: 10.1016/j.cej.2020.127184, vol. 407, Oct. 2020. en_US
dc.identifier.issn 1385-8947
dc.identifier.uri https://doi.org/10.1016/j.cej.2020.127184
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/5821
dc.description.abstract Antineoplastics (anticancer agents) i.e. alkylating and non-alkylating agents, topoisomerase inhibitors etc. are classified as the contaminants of emerging concern due to growing concern about environmental health degradation. Such cytostatic agents contain a suit of functional groups (i.e. folic acid/purine/pyrimidine/nitrogen analogues), which render their complex chemistry and determine partitioning in the aquatic systems. A systematic review of the recent literature published between 2009 and 2020 has been presented to validate the hypothesis that the environmental fate, distribution, and removal aspects of chemotherapeutic agents depend largely on the structural orientation, environmental (and genetic) factors, and degree of ionization. The key knowledge gaps on the current challenges and opportunities of research trends of cytostatic drugs (and their derivatives) in the environment have been identified and critically discussed. This review provides an overview of risk assessment of pyrimidine antimetabolites and topoisomerase inhibitors, which is need of the hour considering their increasing consumption and state-of-the-art analytical detection. The main focus of the review is that a cocktail mixture of tamoxifen, 5-fluorouracil and other active metabolites of polar, water soluble antineoplastic agents may have the accumulation effect on the aquatic species. They can spread drug resistance via their interaction with some kinases.
dc.description.statementofresponsibility by Santanu Mukherjee, Dip Mehta, Kiran Dhangar and Manish Kumar
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Cytostatic en_US
dc.subject Cytotoxic en_US
dc.subject Cellular Resistance en_US
dc.subject Cell Regulation en_US
dc.subject Polar Metabolites en_US
dc.subject Topoisomerase Inhibitors en_US
dc.title Environmental fate, distribution and state-of-the-art removal of antineoplastic drugs: a comprehensive insight en_US
dc.type Article en_US
dc.relation.journal Chemical Engineering Journal


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