Hybrid spectral-IRDx: near-IR and ultrasound attenuation system for differentiating breast cancer from adjacent normal tissue

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dc.contributor.author Pal, Uttam
dc.contributor.author Nayak, Ashika
dc.contributor.author Medisetti, Tejaswi
dc.contributor.author Gogoi, Gayatri
dc.contributor.author Shekhar, Himanshu
dc.contributor.author Prasad, Msn
dc.contributor.author Vaidya, Jayant S.
dc.contributor.author Pandya, Hardik Jeetendra
dc.coverage.spatial United States of America
dc.date.accessioned 2021-05-14T05:18:50Z
dc.date.available 2021-05-14T05:18:50Z
dc.date.issued 2021-12
dc.identifier.citation Pal, Uttam; Nayak, Ashika; Medisetti, Tejaswi; Gogoi, Gayatri; Shekhar, Himanshu; Prasad, Msn; Vaidya, Jayant S. and Pandya, Hardik Jeetendra, “Hybrid spectral-IRDx: near-IR and ultrasound attenuation system for differentiating breast cancer from adjacent normal tissue”, IEEE Transactions on Biomedical Engineering, DOI: 10.1109/TBME.2021.3077582, vol. 68, no. 12, pp. 3554-3563, Dec. 2021. en_US
dc.identifier.issn 0018-9294
dc.identifier.issn 1558-2531
dc.identifier.uri https://doi.org/10.1109/TBME.2021.3077582
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/6508
dc.description.abstract Objective: While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the cancer to achieve complete resection. The current standard is histopathology; however, it is time-consuming and labour-intensive requiring skilled personnel. Method: We describe a Hybrid Spectral-IRDx - a combination of the previously reported Spectral-IRDx tool with multimodal ultrasound and NIR spectroscopy techniques. We show how this portable, cost-effective, minimal-contact tool could provide rapid diagnosis of cancer using formalin-fixed (FF) and deparaffinized (DP) breast biopsy tissues. Results: Using this new tool, measurements were performed on cancerous/fibroadenoma and its adjacent normal tissues from the same patients (N=14). The acoustic attenuation coefficient () and reduced scattering coefficient (s) (at 850, 940, and 1060 nm) for the cancerous/fibroadenoma tissues were reported to be higher compared to adjacent normal tissues, a basis of delineation. Comparing FF cancerous and adjacent normal tissue, the difference in s at 850 nm and 940 nm were statistically significant (p=3.17e-2 and 7.94e-3 respectively). The difference in between the cancerous and adjacent normal tissues for DP and FF tissues were also statistically significant (p=2.85e-2 and 7.94e-3 respectively). Combining multimodal parameters and s (at 940 nm) show highest statistical significance (p=6.72e-4) between FF cancerous/fibroadenoma and adjacent normal tissues. Conclusion: We show that Hybrid Spectral-IRDx can accurately delineate between cancerous and adjacent normal breast biopsy tissue. Significance: The results obtained establish the proof-of-principle and large-scale testing of this multimodal breast cancer diagnostic platform for core biopsy diagnosis.
dc.description.statementofresponsibility by Uttam Pal, Ashika Nayak,Tejaswi Medisetti, Gayatri Gogoi, Himanshu Shekhar, Msn Prasad, Jayant S. Vaidya, Hardik Jeetendra Pandya
dc.format.extent vol. 68, no. 12, pp. 3554-3563
dc.language.iso en_US en_US
dc.publisher Institute of Electrical and Electronics Engineers en_US
dc.subject Ultrasonic imaging en_US
dc.subject Ultrasonic variables measurement en_US
dc.subject Optical attenuators en_US
dc.subject Biopsy en_US
dc.subject Biomedical optical imaging en_US
dc.subject Optical imaging en_US
dc.subject Acoustic measurements en_US
dc.title Hybrid spectral-IRDx: near-IR and ultrasound attenuation system for differentiating breast cancer from adjacent normal tissue en_US
dc.type Article en_US
dc.relation.journal IEEE Transactions on Biomedical Engineering

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