Constitutive-Law Modeling of Microfilaments From Their Discrete-Structure Simulations—A Method Based on an Inverse Approach Applied to a Static Rod Model

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dc.contributor.author Hinkle, Adam R.
dc.contributor.author Goyal, Sachin
dc.contributor.author Palanthandalam-Madapusi, Harish
dc.date.accessioned 2014-03-16T11:54:20Z
dc.date.available 2014-03-16T11:54:20Z
dc.date.issued 2012-06
dc.identifier.citation Hinkle, Adam R.; Goyal, Sachin and Palanthandalam-Madapusi, Harish, “Constitutive-law modeling of microfilaments from their discrete-structure simulations: A method based on an inverse approach applied to a Static rod model”, Journal of Applied Mechanics, DOI: 10.1115/1.4006449, vol. 79, no.5, pp. 051005(7), Jun. 2012. en_US
dc.identifier.issn 0021-8936
dc.identifier.uri http://dx.doi.org/10.1115/1.4006449
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/781
dc.description.abstract Twisting and bending deformations are crucial to the biological functions of several microfilaments such as DNA molecules. Although continuum-rod models have emerged as efficient tools to describe the nonlinear dynamics of these deformations, a major roadblock in the continuum–mechanics-based description of microfilaments is the accurate modeling of the constitutive law, which follows from their atomistic-level structure and interactions. In this paper, we present a method for estimating the constitutive law using a static rod model and deformed configuration data generated from discrete-structure simulations. Furthermore, we illustrate the method on a filament with an artificial discrete-structure. We simulate its deformation in response to a prescribed loading using a multibody dynamics (MBD) solver. Using position data generated from the MBD solver, we first estimate the curvature of the filament, and subsequently use it to estimate the effective relationship between the restoring moment and curvature. en_US
dc.description.statementofresponsibility by Adam R. Hinkle, Sachin Goyal and Harish J. Palanthandalam-Madapusi
dc.format.extent Vol. 79, No.5, pp. 051005(7)
dc.language.iso en en_US
dc.publisher American Society of Mechanical Engineers (ASME) en_US
dc.subject Accurate modeling en_US
dc.subject Bending deformations en_US
dc.subject Biological functions en_US
dc.subject Constitutive law en_US
dc.subject DNA molecules en_US
dc.subject Inverse approach en_US
dc.subject Microfilaments en_US
dc.subject Multi-body dynamic en_US
dc.subject Position data en_US
dc.subject Restoring moments en_US
dc.subject Rod model en_US
dc.title Constitutive-Law Modeling of Microfilaments From Their Discrete-Structure Simulations—A Method Based on an Inverse Approach Applied to a Static Rod Model en_US
dc.type Article en_US
dc.relation.journal Journal of Applied Mechanics


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