Social Factors and Leukocyte DNA Methylation of Repetitive Sequences: The Multi-Ethnic Study of Atherosclerosis

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dc.contributor.author Subramanyam, Malavika A.
dc.contributor.author Pilsner, J. Richard
dc.contributor.author Villamor, Eduardo
dc.contributor.author Donohue, Kathleen M.
dc.contributor.author Liu, Yongmei
dc.contributor.author Jenny, Nancy S.
dc.contributor.author Diez Roux, Ana V.
dc.date.accessioned 2014-03-17T14:31:07Z
dc.date.available 2014-03-17T14:31:07Z
dc.date.issued 2013-01-08
dc.identifier.citation Subramanyam, Malavika A. et al., “Social factors and leukocyte DNA methylation of repetitive sequences: The multi-ethnic study of atherosclerosis”, PLoS ONE, DOI: 10.1371/journal.pone.0054018, vol. 8, no. 1, pp. e54018, Jan. 2013. en_US
dc.identifier.issn 1932-6203
dc.identifier.uri http://dx.doi.org/10.1371/journal.pone.0054018
dc.identifier.uri https://repository.iitgn.ac.in/handle/123456789/895
dc.description.abstract Epigenetic changes are a potential mechanism contributing to race/ethnic and socioeconomic disparities in health. However, there is scant evidence of the race/ethnic and socioeconomic patterning of epigenetic marks. We used data from the Multi-Ethnic Study of Atherosclerosis Stress Study (N = 988) to describe age- and gender- independent associations of race/ethnicity and socioeconomic status (SES) with methylation of Alu and LINE-1 repetitive elements in leukocyte DNA. Mean Alu and Line 1 methylation in the full sample were 24% and 81% respectively. In multivariable linear regression models, African-Americans had 0.27% (p<0.01) and Hispanics 0.20% (p<0.05) lower Alu methylation than whites. In contrast, African-Americans had 0.41% (p<0.01) and Hispanics 0.39% (p<0.01) higher LINE-1 methylation than whites. These associations remained after adjustment for SES. In addition, a one standard deviation higher wealth was associated with 0.09% (p<0.01) higher Alu and 0.15% (p<0.01) lower LINE-1 methylation in age- and gender- adjusted models. Additional adjustment for race/ethnicity did not alter this pattern. No associations were observed with income, education or childhood SES. Our findings, from a large community-based sample, suggest that DNA methylation is socially patterned. Future research, including studies of gene-specific methylation, is needed to understand better the opposing associations of Alu and LINE-1 methylation with race/ethnicity and wealth as well as the extent to which small methylation changes in these sequences may influence disparities in health. en_US
dc.description.statementofresponsibility by Malavika A. Subramanyam et al.,
dc.format.extent Vol. 8, No. 1, pp. e54018
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.subject African Americans en_US
dc.subject African Americans en_US
dc.subject Atherosclerosis en_US
dc.subject DNA Methylation en_US
dc.subject Ethnic Groups en_US
dc.subject European Continental Ancestry Group en_US
dc.subject Genomic DNA en_US
dc.subject Hispanic Americans en_US
dc.title Social Factors and Leukocyte DNA Methylation of Repetitive Sequences: The Multi-Ethnic Study of Atherosclerosis en_US
dc.type Article en_US
dc.relation.journal PLoS ONE


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