Social Factors and Leukocyte DNA Methylation of Repetitive Sequences: The Multi-Ethnic Study of Atherosclerosis

Show simple item record Subramanyam, Malavika A. Pilsner, J. Richard Villamor, Eduardo Donohue, Kathleen M. Liu, Yongmei Jenny, Nancy S. Diez Roux, Ana V. 2014-03-17T14:31:07Z 2014-03-17T14:31:07Z 2013-01-08
dc.identifier.citation Subramanyam, Malavika A. et al., “Social factors and leukocyte DNA methylation of repetitive sequences: The multi-ethnic study of atherosclerosis”, PLoS ONE, DOI: 10.1371/journal.pone.0054018, vol. 8, no. 1, pp. e54018, Jan. 2013. en_US
dc.identifier.issn 1932-6203
dc.description.abstract Epigenetic changes are a potential mechanism contributing to race/ethnic and socioeconomic disparities in health. However, there is scant evidence of the race/ethnic and socioeconomic patterning of epigenetic marks. We used data from the Multi-Ethnic Study of Atherosclerosis Stress Study (N = 988) to describe age- and gender- independent associations of race/ethnicity and socioeconomic status (SES) with methylation of Alu and LINE-1 repetitive elements in leukocyte DNA. Mean Alu and Line 1 methylation in the full sample were 24% and 81% respectively. In multivariable linear regression models, African-Americans had 0.27% (p<0.01) and Hispanics 0.20% (p<0.05) lower Alu methylation than whites. In contrast, African-Americans had 0.41% (p<0.01) and Hispanics 0.39% (p<0.01) higher LINE-1 methylation than whites. These associations remained after adjustment for SES. In addition, a one standard deviation higher wealth was associated with 0.09% (p<0.01) higher Alu and 0.15% (p<0.01) lower LINE-1 methylation in age- and gender- adjusted models. Additional adjustment for race/ethnicity did not alter this pattern. No associations were observed with income, education or childhood SES. Our findings, from a large community-based sample, suggest that DNA methylation is socially patterned. Future research, including studies of gene-specific methylation, is needed to understand better the opposing associations of Alu and LINE-1 methylation with race/ethnicity and wealth as well as the extent to which small methylation changes in these sequences may influence disparities in health. en_US
dc.description.statementofresponsibility by Malavika A. Subramanyam et al.,
dc.format.extent Vol. 8, No. 1, pp. e54018
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.subject African Americans en_US
dc.subject African Americans en_US
dc.subject Atherosclerosis en_US
dc.subject DNA Methylation en_US
dc.subject Ethnic Groups en_US
dc.subject European Continental Ancestry Group en_US
dc.subject Genomic DNA en_US
dc.subject Hispanic Americans en_US
dc.title Social Factors and Leukocyte DNA Methylation of Repetitive Sequences: The Multi-Ethnic Study of Atherosclerosis en_US
dc.type Article en_US
dc.relation.journal PLoS ONE

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Digital Repository


My Account