The present disclosure relates to styryl N-oxide fluorophores for Fe2+ driven lipid droplets imaging. Particularly the present disclosure relates to styryl N-oxide fluorophores for Fe2+ driven lipid droplets imaging and detecting labile heme and ferroptosis through �turn � on� fluorescence. Two simple water-soluble �turn � on� fluorescent probes, NOPy and NOCN are developed, for rapid and selective detection of Fe(II) at nanomolar levels, accompanied by significant absorption and emission shifts, along with colorimetric demarcation. Both fluorophores exhibit an excellent �turn � on� emission response upon encountering Fe2+ in the cells.