NEW AND ALTERNATIVE APPROACHES TO COMBAT ANTIBIOTIC RESISTANCE

Inappropriate, indiscriminate and widespread antibiotic use escalates antibiotic resistant cases and generates public health predicament due to limited synthetic approaches for manufacturing newer antibiotic and limited resource of antibiotic production as most of the environmental bacteria are uncultivable. Newer promising approaches such as catalytic antibiotic, use of DNAzymes or antisense oligonucleotide (ASO) for inactivating m-RNA that encode for antibiotic resistant protein, inactivation of efflux pump and disruption of the MecR1 regulatory pathway and exploration of newer antibiotic resources via screening of soil bacteria or other methods, may help in combating the existing gigantic antibiotic resistance issue.