KRAS mutations are known to be the most recurrent gain-of-function changes instigated in patients with cancer. The RAS gene family is often mutated in most of the human cancers and the pursuit of inhibitors that bind to ...
Thambi, Varsha; Gautam, Abhay Raj Singh; Khatua, Saumyakanti(Royal Society of Chemistry, 2020-08)
Bimetallic hollow core-shell nanoparticles have gained immense attention especially, as a high-performance catalyst due to their large surface area and increased number of uncoordinated atoms. But, the synthesis of anisotropic ...
Pandey, Shalini; Nandi, Aditi; Basu, Sudipta; Ballav, Nirmalya(Royal Society of Chemistry, 2020-08)
Endoplasmic reticulum is one of the vital organelles primarily involved in protein synthesis, folding, transport and lipid biosynthesis. However, in cancer cells its functions are dysregulated leading to ER stress. ER ...
Pyridopyrimidinones are class of heterocyclic compounds which serves as important precursors in organic transformation and medicinal chemistry. In the current work three derivatives of pyrido[1,2-a]pyrimidine-3-carboxylates ...
End-to-end dimers of gold nanorods are predicted to be excellent substrates for surface-enhanced spectroscopy. However, synthesis of solution-stable end-to-end dimers remains challenging. Here we exploit the pH-dependent ...
Background: The importance of inhibiting the kinases of the DDR pathway for radiosensitizing cancer cells is well established. Cancer cells exploit these kinases for their survival which leads to the development of resistance ...
Kar, Ashish; Thambi, Varsha; Paital, Diptiranjan; Khatua, Saumyakanti(Royal Society of Chemistry, 2020-05)
End-to-end assemblies of anisotropic plasmonic nanostructures with small nanogaps are of great interest as they create strong hot spots for enhancing weak fluorescence and/or scattering of molecules. Here we report the ...
The effective disposal of ever-increasing electronic waste (e-waste) is one of the grand challenges for the scientific and technological community today. As e-waste has exponentially been increasing the burden on our ...
Kushwah, H.; Hans, Tanya; Chauhan, M.; Mittal, G.; Sandal, N.(Springer Verlag, 2020-07)
The main objective of the present study is a quantitative determination of menthol using a simple, sensitive, and reproducible method of reacting menthol with an aromatic aldehyde (salicylaldehyde) in an acidic medium. A ...
La2?2xBi2xO3 (x=0?0.04) nanocrystalline powders are synthesized by one?pot single step solution combustion method. 4 atom% Bi doped La2O3 reveals the presence of both Bi3+ and metallic Bi. Temperature programmed reduction ...
Jana, Palash; Siva, Aravintha; Soppina, Virupakshi; Kanvah, Sriram(Royal Society of Chemistry, 2020-06)
Lipid droplets (LDs), the lipid-rich intracellular organelles, serve to regulate many physiological processes and therefore attention has been attracted towards their selective detection. We report positively solvatochromic ...
Jana, Palash; Kanvah, Sriram et al.(American Chemical Society, 2020-06)
Although luminescence spectroscopy has been a promising sensing technology with widespread applications in point-of-care diagnostics and chem-bio detection, it fundamentally suffers from low signal collection efficiency, ...
Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, ...
Dolui, Dependu; Khandelwal, Shikha; Majumder, Piyali; Dutta, Arnab(Royal Society of Chemistry, 2020-06)
Cobaloxime complex gained the attention for its intrinsic ability of catalytic H2 production, despite its initial emergence as a Vitamin B12 model. The simple, robust, and a synthetically manoeuvrable cobaloxime core ...
A series of 10H-substituted phenothiazine-based molecules were prepared by the base-catalyzed reactions. The synthesized compounds are characterized by Mass spectroscopy, NMR, and SCXRD to examine the role of different ...
The synthesis of water-soluble thioglycosylated A2B2 type porphyrins and their zinc(II) complexes is reported. The water-soluble trans-A2B2 porphyrins were synthesized in two steps, via [2+2] condensation between ...
Sarkale, Abhijeet M.; Appayee, Chandrakumar(American Chemical Society, 2020-05)
A first stereodivergent strategy for the asymmetric synthesis of all stereoisomers of 1-hydroxymethylpyrrolizidine alkaloids is developed using an asymmetric self-Mannich reaction as a key step. An anti-selective self-Mannich ...
Ras is a small family of GTPases that control numerous cellular functions like cell proliferation, growth, survival, gene expression, and is closely engaged in cancer pathogenesis. The ras-targeted methodology entails a ...