Inhibitors of carbonic anhydrase (CAIs) hold promise for addressing various diseases, including cancer, diabetes, and other metabolic syndromes. CAV is the only isoform present in the mitochondria and is considered a ...
Dolui, Dependu; Mir, Ab Qayoom; Dutta, Arnab(Royal Society of Chemistry, 2020-11)
The incorporation of amine functionality in the periphery of a synthetic cobaloxime core induces excellent photo-(TON 180) and electrocatalytic H2 production (TOF 4330 s?1) in aqueous solution. The primary amine group ...
Li, Dan; Kumari, Beena; Makabenta, Jessa Marie; Tao, Bailong; Qian, Kun; Mei, Xifan; Rotello, Vincent M.(Royal Society of Chemistry, 2020-09)
Infections from antibiotic-resistant bacteria have caused huge economic loss and numerous deaths over the past decades. Researchers are exploring multiple strategies to combat these bacterial infections. Metal nanomaterials ...
Sensitive detection of nitroaromatic explosives such as picric acid is critical. Among various known methods, materials exhibiting aggregation-induced emission (AIE) have emerged as fascinating candidates for sensing ...
Kediya, Siddhi; Manhas, Anu; Lone, Mohsin Y. and Jha, Prakash C.(Elsevier, 2020-10)
Theoretical methods (DFT/TD-DFT) were applied to study the sensing mechanism of triarylborane naphthalimide. The free-energy and binding-energy change revealed more feasibility and binding affinity of fluoride in comparison ...
KRAS mutations are known to be the most recurrent gain-of-function changes instigated in patients with cancer. The RAS gene family is often mutated in most of the human cancers and the pursuit of inhibitors that bind to ...
Thambi, Varsha; Gautam, Abhay Raj Singh; Khatua, Saumyakanti(Royal Society of Chemistry, 2020-08)
Bimetallic hollow core-shell nanoparticles have gained immense attention especially, as a high-performance catalyst due to their large surface area and increased number of uncoordinated atoms. But, the synthesis of anisotropic ...
Pandey, Shalini; Nandi, Aditi; Basu, Sudipta; Ballav, Nirmalya(Royal Society of Chemistry, 2020-08)
Endoplasmic reticulum is one of the vital organelles primarily involved in protein synthesis, folding, transport and lipid biosynthesis. However, in cancer cells its functions are dysregulated leading to ER stress. ER ...
Pyridopyrimidinones are class of heterocyclic compounds which serves as important precursors in organic transformation and medicinal chemistry. In the current work three derivatives of pyrido[1,2-a]pyrimidine-3-carboxylates ...
End-to-end dimers of gold nanorods are predicted to be excellent substrates for surface-enhanced spectroscopy. However, synthesis of solution-stable end-to-end dimers remains challenging. Here we exploit the pH-dependent ...
Background: The importance of inhibiting the kinases of the DDR pathway for radiosensitizing cancer cells is well established. Cancer cells exploit these kinases for their survival which leads to the development of resistance ...
Kar, Ashish; Thambi, Varsha; Paital, Diptiranjan; Khatua, Saumyakanti(Royal Society of Chemistry, 2020-05)
End-to-end assemblies of anisotropic plasmonic nanostructures with small nanogaps are of great interest as they create strong hot spots for enhancing weak fluorescence and/or scattering of molecules. Here we report the ...
The effective disposal of ever-increasing electronic waste (e-waste) is one of the grand challenges for the scientific and technological community today. As e-waste has exponentially been increasing the burden on our ...
Kushwah, H.; Hans, Tanya; Chauhan, M.; Mittal, G.; Sandal, N.(Springer Verlag, 2020-07)
The main objective of the present study is a quantitative determination of menthol using a simple, sensitive, and reproducible method of reacting menthol with an aromatic aldehyde (salicylaldehyde) in an acidic medium. A ...
La2?2xBi2xO3 (x=0?0.04) nanocrystalline powders are synthesized by one?pot single step solution combustion method. 4 atom% Bi doped La2O3 reveals the presence of both Bi3+ and metallic Bi. Temperature programmed reduction ...
Jana, Palash; Siva, Aravintha; Soppina, Virupakshi; Kanvah, Sriram(Royal Society of Chemistry, 2020-06)
Lipid droplets (LDs), the lipid-rich intracellular organelles, serve to regulate many physiological processes and therefore attention has been attracted towards their selective detection. We report positively solvatochromic ...
Jana, Palash; Kanvah, Sriram et al.(American Chemical Society, 2020-06)
Although luminescence spectroscopy has been a promising sensing technology with widespread applications in point-of-care diagnostics and chem-bio detection, it fundamentally suffers from low signal collection efficiency, ...