Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, ...
Dolui, Dependu; Khandelwal, Shikha; Majumder, Piyali; Dutta, Arnab(Royal Society of Chemistry, 2020-06)
Cobaloxime complex gained the attention for its intrinsic ability of catalytic H2 production, despite its initial emergence as a Vitamin B12 model. The simple, robust, and a synthetically manoeuvrable cobaloxime core ...
A series of 10H-substituted phenothiazine-based molecules were prepared by the base-catalyzed reactions. The synthesized compounds are characterized by Mass spectroscopy, NMR, and SCXRD to examine the role of different ...
Ras is a small family of GTPases that control numerous cellular functions like cell proliferation, growth, survival, gene expression, and is closely engaged in cancer pathogenesis. The ras-targeted methodology entails a ...
The synthesis of water-soluble thioglycosylated A2B2 type porphyrins and their zinc(II) complexes is reported. The water-soluble trans-A2B2 porphyrins were synthesized in two steps, via [2+2] condensation between ...
Sarkale, Abhijeet M.; Appayee, Chandrakumar(American Chemical Society, 2020-05)
A first stereodivergent strategy for the asymmetric synthesis of all stereoisomers of 1-hydroxymethylpyrrolizidine alkaloids is developed using an asymmetric self-Mannich reaction as a key step. An anti-selective self-Mannich ...
A novel approach for Hydrazine assisted electrolytic hydrogen production using nanocoral structures of cobalt-copper sulfide is portrayed in this work. It is observed that an enormous amount of hydrogen is produced with ...
The construction of an efficient, inexpensive, and durable H2 production electrocatalyst is considered as an indispensable tool for the inception of a hydrogen-mediated alternative energy technology. Recently, cobalt-based ...
Conversion of carbon dioxide into selective hydrocarbon using a stable catalyst remains a holy grail in the catalysis community. The high overpotential, stability, and selectivity in the use of a single-metal-based catalyst ...
Pandey, Shalini; Patil, Sohan; Ballav, Nirmalya; Basu, Sudipta(Royal Society of Chemistry, 2020-04)
The presence of the same proteins at different sub-cellular locations with completely different functions adds to the complexity of signalling pathways in cancer. Subsequently, it becomes indispensable to understand the ...
Kutwal, Mahesh S.; Padmaja, Venkata M. D.; Appayee, Chandrakumar(Wiley, 2020-03)
The first regio? and enantioselective organocatalytic cascade ?,? ?dialkylation of ? , ? ?unsaturated aldehydes is achieved. Substrates scope is demonstrated with a variety of ? , ? ?unsaturated aldehydes and alkylating ...
Renewable harvesting of clean energy using the benefits of multi-metallic catalytic materials of high entropy alloy (HEA, equimolar Cu�Ag�Au�Pt�Pd) from formic acid with minimum energy input has been achieved in the present ...
Angira, Deekshi; Shaik, Althaf; Thiruvenkatam, Vijay(Frontiers in Bioscience, 2020-03)
Phosphatidylinositol-3 kinase-related kinases (PIKKs) is a class of six unique serine/threonine kinases that are characterized as high molecular mass colossal proteins present in multicellular organisms. They predominantly ...
Shaik, Althaf; Kirubakaran, Sivapriya(Frontiers in Bioscience, 2020-03)
Phosphatidylinositol-3 kinase-related kinases (PIKKs) belong to a family of atypical serine/threonine kinases in humans. They actively participate in a diverse set of cellular functions such as meiotic, V(D)J recombination, ...
Microtubule associated protein Tau (MAPT) is a phospho-protein within neurons of the brain. Aggregation of tau is the leading cause of tauopathies such as Alzheimer�s disease. Tau undergoes several post-translational ...
The potential of using insect proteins to encapsulate and protect hydrophobic nutraceuticals within biopolymer nano-complexes was examined. Insect proteins were used to form nanoparticles that were uncoated or coated with ...