Multi-objective control of a fed-batch bioreactor using shrinking horizon MPC: A case study

This work focuses on offline and online multi-objective control of a fed-batch bioreactor for the induced foreign protein production by recombinant bacteria. Initially, open loop multi-objective control problem is formulated and solved using a single objective optimization after augmenting the individual objectives. The weighting parameters in the augmented objective function represent their priorities. The lexicographic optimization approach has been utilized for the multi-objective control in the MPC framework. Moreover, unlike the continuous processes, the batch processes operate for a definite batch time. Hence, the shrinking horizon approach along with the economic MPC framework is employed in the fed-batch bioreactor control.